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Biomedical subjects

T Djarova

Publications and source records attributed to T Djarova.

4 recordsLinked to original sources
PubMed1990

Hormonal and cardiorespiratory changes following simulated saturation dives to 4 and 11 ATA.

Professional divers were compressed with trimix to 4 ATA (2 persons, aged 35 and 26) and to 11 ATA (3 persons, aged 34, 26, and 23) for saturation dives with durations of 48 and 50 h, followed by 33 and 109 h of decompression, respectively. Pre- and postdive cardiorespiratory reactions to a step test--heart rate (HR) and ventilation (VE)--and concentrations of growth hormone, corticotropin, cortisol, insulin, lutotropin, folitropin, triiodothyronine (T3), thyroxine (T4), thyrotropin, and testosterone in serum were studied. All divers developed postdecompression tachycardia (90-108 beats/min), which persisted 24 h after surfacing. Physical fitness assessed by steady state HR and VE during a step test was lowered 24 h after decompression compared with the predive values in 4 divers and enhanced in 1. These data provide evidence for hindered and delayed readaptation of the cardiorespiratory system to a normobaric environment. T3, T4, and testosterone were significantly decreased postdive. Hormonal responses were found to exhibit a very individual pattern from which it was possible to estimate the adaptive reactions after hyperbaric exposure. Professional divers with a lower level of physical fitness showed more pronounced hormonal responses to hyperbaric environments.

Adaptation, Physiological↗
PubMed1986

Human growth hormone, cortisol, and acid-base balance changes after hyperventilation and breath-holding.

The purpose of this study was to investigate the effects of hyperventilation and breath-holding on hormonal activity and the acid-base balance in men. Three different experimental procedures were carried out with 11 trained subjects aged 24.5 years. In experiment I, all subjects performed hyperventilation for 3 min maintaining a paced ventilation of 47 l X min-1. In experiment II, they performed a threefold maximal voluntary breath-holding, separated by 1-min periods of normal breathing. Experiment III consisted of a combination of hyperventilation immediately followed by maximal voluntary breath-holding. Capillary blood samples were taken for determination of pO2, pCO2, and pH. Venous blood samples were drawn before and at the 5th and 30th min after the cessation of the applied procedure for RIA determination of human growth hormone (HGH) and cortisol. During the last 15 s of hyperventilation, pO2 increased to 89.4 +/- 16.2 mm Hg, pCO2 decreased to 19.6 +/- 1.6 mm Hg, and pH increased to 7.652 +/- 0.041. During the last 15 s of the third breath-holding, the results were pO2 = 58.0 +/- 5.1, pCO2 = 45.7 +/- 3.7, and pH = 7.367 +/- 0.053. In experiment III, the mean values were pO2 = 42.6 +/- 7.9 mmHg, pCO2 = 39.2 +/- 4.6 mmHg, and pH = 7.320 +/- 0.024. A significant hormonal response after the applied experimental procedures was found for HGH (1.5- to 5.56-fold increase) and cortisol (1.5- to 2.2-fold increase).(ABSTRACT TRUNCATED AT 250 WORDS)

Acid-Base Equilibrium↗