Alpha 2 antagonists.
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Adrenergic alpha-Antagonists↗
Biomedical subjects
T Doherty
Publications and source records attributed to T Doherty.
Prediction of the metabolic cost of exercise from measurements during recovery.
This study was designed to determine if post exercise recovery measurements could be used to predict oxygen uptake (VO2), minute ventilation (VE) and heart rates (HR) during exercise. VO2, VE and HR were measured in 11 healthy males during the last minute of treadmill running and during standing recovery. Since it is often impractical to collect data during the first 15 s of recovery in the field, the equations which best predicted the observed last-minute exercise values were obtained from enhanced linear least squares regressions of data collected between 15 and 60 s after cessation of exercise. In a separate validation experiment the mean (S.E.) difference between predicted and observed values for VO2, VE, and HR were 0.08 (0.06) L.min-1, 1.0 (5.1) L.min-1, and 2.2 (1.4) beats.min-1, respectively. We conclude that the equations described in this study may be used to estimate the metabolic cost of exercise in situations where it is impossible to make direct measurements.
Adult↗
Idazoxan: a novel xylazine antagonist.
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Adrenergic alpha-Antagonists↗
Reversal of oxymorphone sedation by naloxone, nalmefene, and butorphanol.
The effects of naloxone (0.4 mg and 1.2 mg intravenously [IV]), nalmefene (0.03 mg/kg IV) and butorphanol (0.2 mg/kg IV and 0.4 mg/kg IV) on oxymorphone-induced sedation were studied in six dogs over a 4-hour observation period. The same dogs were observed for 4 hours untreated (unsedated control) and with oxymorphone sedation followed by saline solution (sedated control). The reversal drug or saline placebo was administered IV 20 minutes after oxymorphone (4.5 mg IV). Blinded observers evaluated the dogs for positional and attitudinal responses, heart rate, and respiratory rate. Sedated dogs treated with nalmefene most closely resembled unsedated dogs in all observed variables. Naloxone was most effective when administered at the higher dose. Mild renarcotization occurred in two dogs at hour 2, even after the higher naloxone dose. Residual sedation was observed in all dogs treated with 0.4 mg naloxone. Butorphanol resulted in partial reversal of sedation at both dosage levels. However, the degree of sedation was significantly less than that observed in the saline-treated controls, and it appeared that 0.4 mg/kg butorphanol may be clinically useful for opiate reversal in some situations.
Animals↗