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Biomedical subjects

T Dolan

Publications and source records attributed to T Dolan.

27 records · Page 2Linked to original sources
PubMed1982

Phase II study of Baker's antifol (triazinate, TZT, NSC-139,105) in advanced squamous cell carcinoma of cervix.

Thirty-two evaluable patients with advanced cervical squamous cell carcinoma were treated with Baker's antifol in a phase II study by the Gynecologic Oncology Group (GOG). There were no complete responses and five partial responses for a response rate of 15.6%. Twenty patients remained stable during the course of therapy; seven had progressive disease. The median number of courses to response was four and the median duration of response was 3 months. The dose-limiting toxicity was dermatitis, which occurred in 10 patients. In four, dermatitis was severe with ulceration and/or desquamation. In two, dermatitis was life threatening and may have contributed to death. Half of the patients had mild or moderate GI side effects; in one case it was severe. Very little hematologic toxicity was observed. No cases of respiratory depression or arrest occurred with this regimen. Baker's antifol has some activity against cervical carcinoma and may be of interest for inclusion in studies of combination therapy because of its relative lack of myelotoxicity.

Adult↗
PubMed1978

Determination of fluoride in deboned meat.

A rapid analytical procedure was investigated for measuring the fluoride content of deboned meat, using a specific ion electrode. The method involves a defatting procedure followed by chelation with EDTA before final solubilization and measurement. Fluoride content is determined by comparison to a standard curve on 2-cycle semi-logarithmic graph paper of fluoride ion vs. millivolt readings. The method is applicable to hand and mechanically deboned pork, beef, and poultry within a range of from 0.7 to 25.0 ppm fluoride. Higher concentrations may be measured by analyzing additional standards and extending the curve into a third cycle. The curve is not linear below 0.7 ppm. Samples less than 0.7 ppm may be estimated by extrapolation. Studies with fortified samples indicate average recoveries of 92 +/- 4.2%. The standard deviation of duplicates within the laboratory is 0.5 ppm in the range stated above.

Animals↗
PubMed1975

Depressed lymphocyte function after measles-mumps-rubella vaccination.

Healthy children receiving routine measles-mumps-rubella vaccine developed an impaired in vitro lymphocyte response to stimulation with antigen (Candida) but not with mitogen (phytohemagglutinin and pokeweed mitogen). Response of lymphocytes was determined by measurement of the amount of [14C]thymidine incorporated by the cells. The impaired response to antigen lasted from one to five weeks after vaccination. There was no alteration in the number of either total or thymus-derived lymphocytes in the peripheral blood after vaccination; These results suggest that viral vaccination causes a depression of lymphocyte function rather than a depletion of functional lymphocytes.

Candida↗