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Biomedical subjects

T Doyle

Publications and source records attributed to T Doyle.

At least 37 records · Page 2Linked to original sources
PubMed1993

Immune responses and chronic lymphedema in experimental filariasis.

Chronic lymphedema is a clinically important manifestation of lymphatic filariasis but the factors which govern the development and progression of lymphedema remain unclear. Because immune responses are major determinants of disease expression in filariasis, we compared immune responses in ferrets reinfected with B. malayi in which disease expression varied from virtually no overt disease to severe chronic lymphedema of the infected limbs. No immune correlates specific for development of chronic lymphedema were identified by antigen recognition profiles (Western-blots), magnitude of the antibody (IgG) responses (ELISA) or blastogenic responses of lymphocytes to filarial extracts. Prausnitz-Kustner (PK) tests for filarial specific IgE indicated that the initial period of a severe lymphedema, which became chronic, often was associated with relatively high IgE titers. The results suggest that a high level of immediate hypersensitivity to filarial antigens is a significant factor in initiating persistent lymphedema on reinfections of partially resistant hosts. Histologic study of persistent edema of up to 2 years duration demonstrated dermal changes consistent with chronic lymphedema, but not the dermal proliferation characteristic of elephantiasis.

Animals↗
PubMed1991

Remembering facial configurations.

Eight experiments are reported showing that subjects can remember rather subtle aspects of the configuration of facial features to which they have earlier been exposed. Subjects saw several slightly different configurations (formed by altering the relative placement of internal features of the face) of each of ten different faces, and they were asked to rate the apparent age and masculinity-femininity of each. Afterwards, subjects were asked to select from pairs of faces the configuration which was identical to one previously rated. Subjects responded strongly to the central or "prototypical" configuration of each studied face where this was included as one member of each test pair, whether or not it had been studied (Experiments 1, 2 and 4). Subjects were also quite accurate at recognizing one of the previously encountered extremes of the series of configurations that had been rated (Experiment 3), but when unseen prototypes were paired with seen exemplars subjects' performance was at chance (Experiment 5). Prototype learning of face patterns was shown to be stronger than that for house patterns, though both classes of patterns were affected equally by inversion (Experiment 6). The final two experiments demonstrated that preferences for the prototype could be affected by instructions at study and by whether different exemplars of the same face were shown consecutively or distributed through the study series. The discussion examines the implications of these results for theories of the representation of faces and for instance-based models of memory.

Adolescent↗
PubMed1991

Recognising facial surfaces.

The extent to which faces depicted as surfaces devoid of pigmentation and with minimal texture cues ('head models') could be matched with photographs (when unfamiliar) and identified (when familiar) was examined in three experiments. The head models were obtained by scanning the three-dimensional surface of the face with a laser, and by displaying the surface measured in this way by using standard computer-aided design techniques. Performance in all tasks was above chance but far from ceiling. Experiment 1 showed that matching of unfamiliar head models with photographs was affected by the resolution with which the surface was displayed, suggesting that subjects based their decisions, at least in part, on three-dimensional surface structure. Matching accuracy was also affected by other factors to do with the view-points shown in the head models and test photographs, and the type of lighting used to portray the head model. In experiment 2 further evidence for the importance of the nature of the illumination used was obtained, and it was found that the addition of a hairstyle (not that of the target face) did not facilitate matching. In experiment 3 identification of the head models by colleagues of the people shown was compared with identification of photographs where the hair was concealed and eyes were closed. Head models were identified less well than these photographs, suggesting that the difficulties in their recognition are not solely due to the lack of hair. Women's heads were disproportionately difficult to recognise from the head models. The results are discussed in terms of their implications for the use of such three-dimensional head models in forensic and surgical applications.

Adolescent↗
PubMed1991

Relationship of progression of radiographic changes in hands and wrists, clinical features and HLA-DR antigens in rheumatoid arthritis.

One hundred and twelve hospital based outpatients with rheumatoid arthritis (mean duration +/- standard error, 10.7 +/- 0.9 years) were studied for radiological progression of the hands and wrists over a mean period of 26.5 +/- 0.5 months. The majority were taking slow acting antirheumatic drugs (SAARD). The rate of radiographic progression was positively and independently associated with the female sex (p less than 0.01), erythrocyte sedimentation rate (ESR, p less than 0.05) and HLA-DR1 (p less than 0.05). There was a negative association with HLA-DR4 (p less than 0.05) but this was no longer significant after adjusting for ESR. There was no relationship between the rate of radiological progression and the presence of rheumatoid factor, rheumatoid nodules and duration of treatment with SAARD.

Arthritis, Rheumatoid↗
PubMed1990

The radiographic changes of scleroderma in the hands.

Hand radiographs from 160 patients with scleroderma were reviewed. The presence of calcinosis distal to the metacarpophalangeal joints was significantly associated with the female sex, disease duration over 10 years, digital ulceration, telangiectasia, tuft erosion and the presence of anticentromere antibodies. The presence of calcinosis proximal to the metacarpophalangeal joints was significantly associated with tuft erosions and erosions involving all joints. The lack of distal calcinosis was significantly associated with anti Scl 70 and antinucleolar antibodies. The prevalence of other radiological manifestations of scleroderma such as osteoarthritis, erosions and dorsal tuft modelling was documented. Specific radiological findings correlate with certain clinical and serological characteristics in scleroderma.

Calcinosis↗
PubMed1990

Computerized tomography mini-series: an alternative to standard paranasal sinus radiographs.

Computerized tomography (CT) imaging provides detailed information on the paranasal sinuses that is not available from standard radiographs. The planning and safety of endoscopic sinus surgery is greatly improved by CT imaging. Frequently standard radiographs are ordered because of the reduced cost. The four-slice CT Mini-series outlined in this paper provides high resolution bone and soft tissue imaging of the key surgical areas. The Mini-series comprises three precisely placed coronal slices and one axial slice. An average Mini-series takes 20 min to perform at a cost of $NZ66.00. Standard radiographs take up to 30 min to perform at a cost of $NZ38.00.

Endoscopy↗
PubMed1989

Further experiments on the perception of growth in three dimensions.

Mark and Todd (1983) reported an experiment in which the cardioidal strain transformation was extended to three dimensions and applied to a three-dimensional (3-D) representation of the head of a 15-year-old girl in a direction that made the transformed head appear younger to the vast majority of their subjects. The experiments reported here extend this research in order to examine whether subjects are indeed detecting cardioidal strain in three dimensions, rather than detecting changes in head slant or making 2-D comparisons of the shape of the occluding contour. Three-dimensional surfaces were obtained by measuring a real head manually (Experiment 1) and with a laser scanner (Experiment 2), and transformed to different age levels using the 3-D strain transformation described by Mark and Todd (1983). There were no statistically significant differences in the accuracy with which relative age judgments could be made in response to pairs of profiles, pairs of 3/4 views, or pairs of mixed views (profile plus 3/4 view), suggesting that subjects can indeed extract the cardioidal strain level of the head in three dimensions. However, an additional effect that emerged in these studies was that judgments were crucially affected by the instructions given to subjects, which suggests that factors other than cardioidal strain are important in making judgments about rich data structures.

Adult↗
PubMed1986

The varying manifestations of Aspergillus lung disease.

The fungus Aspergillus may cause a variety of pulmonary disorders as a result of its ability to act as an allergen, as a simple saprophyte or as an infectious organism. The clinical manifestations range from hypersensitivity syndromes, in which corticosteroid therapy may be indicated, to disseminated infections, in which corticosteroid agents may be causative. The diagnosis may not be immediately apparent. Six cases are presented to illustrate the sometimes confusing manifestations of the disease.

Adult↗
PubMed1986

Chalk in the prime.

After observations of cloudiness in the perfusion circuit at open intracardiac operations, laboratory experiments showed a precipitate in a Hartmann's solution (compound sodium lactate solution, Ringer-lactate) and sodium bicarbonate based priming fluid used for cardiopulmonary bypass. The precipitate was found to consist of calcium carbonate crystals. The crystals were not dissolved by adding plasma proteins, nor were they sufficiently cleared from the extracorporeal circuit by a 40 microns filter in the arterial line. The crystals may embolise in microvascular beds and thus be a cause of postoperative morbidity. The practice of adding sodium bicarbonate to the pump prime may be unnecessary.

Bicarbonates↗