Additional phage-typing scheme for C. diphtheriae.
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Biomedical subjects
Publications and source records attributed to T Drăgoi.
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A number of 700 guinea pigs were immunized by parenteral route with non-toxigenic Corynebacterium diphtheriae strains, then inoculated with various doses of homologous and heterologous toxigenic C. diphitheriae strains. The results showed that non-toxigenic C. diphtheriae strains confer a certain degree of protection when the challenge is done with homologous toxigenous strains, especially when not more than 500 million germs/ml are used for the challenge dose. This suggests that the carriage of non-toxigenic diphtheriae bacilli is a useful phenomenon for maintaining an immune balance in diphtheria in the present epidemiological context, and that their sterilization is not opportune.
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