Biomedical subjects
Publications and source records attributed to T Dziewit.
The study was performed in patients taking Cordafen Polfa 30 mg a day. Just after three days of its administration, impaired basal metabolism of polymorphonuclear granulocytes in NBT test was found. After seven days of Cordafen use was demonstrated. Cordafen has no effect on oxygen metabolic activity in granulocytes stimulated by latex particles.
The increased concentration of malonyl dialdehyde (MDA) in peripheral blood red cells of workers engaged in the production of iron-manganese alloyes was found. That provide evidence that increased peroxidation of red blood cell lipids induced by the production of free radicals is due to factors present in the occupational environment.
In polymorphonuclear granulocytes of men which used nifedipine in daily doses 30 mg during the period of 7 days was found: after 3 days as well after 7 days the lower concentration of copper and the higher concentration of zinc. The vitamin C concentration did not change substantially.
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In red blood cells of men which take nifedipine in daily doses 30 mg was found: lower copper concentration, higher zinc concentration as compared to concentrations of these metals determined before administration of nifedipine. Changes in Cu and Zn blood concentrations were intensified during administration of the drug. The vitamin C concentration did not change substantially.
It was found that nifedipine used in patients in doses 30 mg per day decreased lipids peroxidation in polymorphonuclear granulocytes measured by lower malonyl dialdehyde concentration. In the some time nifedipine enhanced antioxidant activity of granulocytes measured by increased superoxide dismutase and selenium-dependent glutathione peroxidase activities and higher concentration of reduced glutathione.
It was found that 0.051 mmol/l concentration of verapamil inhibits the resting (spontaneous) oxygenic metabolism of the human peripheral blood polymorphonuclear granulocytes. In experiments in vitro it was expressed by the statistically significant lower capacity to reduction of nitroblue tetrazolium (NBT) by the granulocytes incubated with the verapamil solution in comparison with the same capacity without the verapamil solution.
After 3 days of orally administrated cordafen (nifedipine) (30 mg per day divided in 3 equal doses) we revealed in red blood cells: statistically significant decrease of malonyl dialdehyde concentration, statistically significant increase of selenium-dependent glutathione peroxidase activity and superoxide dismutase activity. Also increased mean reduced glutathione concentration in erythrocytes of human peripheral blood was found, though statistically nonsignificant.
The serum lysozyme level of workers engaged in the production of iron-manganese alloys was observed. The lysozyme level was statistically significantly increased compared with the control group. There was no evidence with age and years of work.
In metallurgic workers exposed to manganese, ferric oxides, chromates, noise, thermal radiation and enhanced temperature in surroundings, a lower level of alpha 2-macroglobulin at an unlowered level of alpha 1-antitrypsin was observed. There was no relationship between either the length of employment or chronic bronchitis and level of alpha 1-antitrypsin and alpha 2-macroglobulin in the blood of workers under study.
Out of 205 workers employed at production of iron-manganese alloys in 35.6% chronic bronchitis (CB) was found. In 11.1% CB occurred in non-smokers, and in 42.5% in cigarette smokers. The incidence of CB was increasing with the number of smoked cigarettes, and in the workers with smoking index < or = 10 it was 53.3% (smoking index = number of cigarette packs smoked daily (1 pack = 20 cigarettes) x number of smoking years). No influence of occupation environment was found on the incidence of CB in the studied workers.
In 30 patients the metabolic activity of the neutrophils measured with the reduction ability of nitroblue tetrazolium was determined after intravenous administration of iodinated contrast media for cholangiography or urography. It was shown that 20 minutes after intravenous injection of the contrast medium the metabolic activity of phagocytizing granulocytes increased steeply and returned to the initial value after 24 hours.
Significantly lower blood serum concentrations of triiodothyronine (T3) and thyroxine (T4) accompanied by a significantly higher concentration of thyrotropin (TSH) have been found in workers exposed to the environmental presence of manganese, iron chromates and other agents as compared to the control group (differing with respect to the environmental exposure to manganese only).
In workers chronically exposed to manganese who showed spirometric abnormalities, an evaluation was done of the degree of ventilation disturbances in relation to age, duration of work, cigarette smoking, and the presence of chronic bronchitis. It was shown that of greatest influence on the loss of ventilation efficacy was cigarette smoking, and, in a lower degree, age. Chronic bronchitis however, caused no greater impairment of ventilation efficacy. Duration of work remained almost without influence on the degree of ventilation impairment.