Handpiece sterilization.
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Biomedical subjects
Publications and source records attributed to T E Balanyk.
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One-hundred forty-nine (149) healthy adult subjects completed a single-use, supervised trial, and 143 subjects completed a 6-week trial to determine the effect of rinsing with Plax prebrushing mouthrinse on supragingival plaque reduction. During the single-use trial, plaque was scored both initially and after subjects rinsed with Plax or a negative control rinse and then brushed with a dentifrice. Following a dental prophylaxis subjects then began a "home-use" phase of rinsing prior to normal brushing, twice daily for 6 weeks, at which time plaque was rescored. In the single-use trial, Plax and control rinses produced 21% and 22% reductions in plaque scores respectively. In the 6-week trial, Plax and control rinses produced 10% and 11% reductions in plaque scores respectively. In all cases, Plax was no more effective than the control rinse in enhancing the plaque-removal effectiveness of toothbrushing.
A critical comparison of the numerous clinical studies on sanguinarine indicates an extreme divergence of reported effects on plaque/gingivitis, ranging from significant reductions to findings of no detectable effect. These equivocal findings stem from numerous short-term studies and fewer long-term studies employing divergent experimental methods. The long-term performance of the sanguinarine mouthrinse or dentifrice, alone or in combined use, still remains to be firmly demonstrated and replicated. The majority of clinical trials fail to demonstrate consistent clinical benefits from the use of this agent.