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Biomedical subjects

T E Brewer

Publications and source records attributed to T E Brewer.

9 recordsLinked to original sources
PubMed1989

Modified open renal biopsy. An experience with fifty consecutive cases.

Fifty consecutive patients underwent a modified open renal biopsy using bronchial forceps under general anesthesia. A small incision (2-3 cm) was made, and several small pieces of renal tissue (5-7) were excised in each case. Adequate tissue for diagnosis was obtained in 100% of the biopsies. Morbidity was minimal, and no deaths occurred as a result of biopsy. Traditionally, the open renal biopsy consists of a large incision (7-10 cm) with a deep wedge excision. It is significant that the modified technique provided a high tissue yield (the average number of glomeruli was 80) with few complications. This tissue yield was significantly higher than that usually seen with percutaneous needle biopsy.

Adult↗
PubMed1981

Partial characterization of a Trypanosoma cruzi-released decomplementing factor.

Trypanosoma cruzi releases a factor (SCAF) when grown in vitro which decomplements normal mouse, human, and guinea pig sera. The production and potency of SCAF was dependent on the density of cultured parasites, parasite viability and proliferative capacity, and duration of culture. The in vitro interaction between SCAF and serum complement (C') occurred rapidly and was complete within 30 min of mixing. The administration of SCAF to normal mice resulted in up to 50% reduction in hemolytic C' activity, whereas SCAF had no effect on the C' levels in mice infected wit T. cruzi for more than 10 days. The active moiety of SCAF was shown to be a nonproteinaceous substance(s) with a molecular weight of approximately 23,000 daltons.

Animals↗
PubMed1980

Vancomycin penetration into CSF during treatment of patients receiving hemodialysis.

Penetration of vancomycin into CSF was determined during therapy with the regimens recently used to treat staphylococcal infections in patients receiving hemodialysis: 1 gm weekly or 750 mg twice weekly. During three episodes in two patients with proved or suspected central nervous system infection, CSF levels of vancomycin ranged from < 0.5 to 1.54 microgram/ml; in only two of six CSF specimens did the antibiotic level exceed its in vitro inhibitory concentration for the infecting organism. Thus, the vancomycin hemodialysis regimens may provide marginal to subtherapeutic CSF drug levels.

Adult↗