PubMed Health⌕ Search

Biomedical subjects

T E Forrester

Publications and source records attributed to T E Forrester.

44 records · Page 3Linked to original sources
PubMed1984

Proteinuria and glomerular disease in Jamaica.

Clinical, laboratory and renal biopsy data on 50 adult patients investigated in Jamaica because of proteinuria of more than 1 g/day were reviewed. Primary glomerular disease was present in 23 cases and the most common histological pattern was mesangial proliferation. Proteinuria was part of a systemic disease in 27 patients of whom 19 had systemic lupus erythematosus (SLE). Urinary protein excretion was less in patients with systemic diseases than in those with primary glomerulonephritis, but hypoalbuminemia, renal function and presence of edema were not helpful in distinguishing types and causes of renal disease. By comparison with other countries SLE and mesangial proliferative glomerulonephritis are common causes of proteinuria and nephrotic syndrome in Jamaica whereas idiopathic membranous glomerulonephropathy appears to be rare.

Adolescent↗
PubMed1981

Sodium, potassium, and rate constants for sodium efflux in leucocytes from hypertensive Jamaicans.

Leucocyte sodium and potassium content and concentrations were measured along with ouabain-sensitive and ouabain-insensitive rate constants for sodium efflux in 14 controls and 20 black patients with essential hypertension. Leucocyte sodium content was significantly increased in the patients (mean 101.1 +/- 7.8 mmol/kg dry solids v 74.5 +/- 7.6 mmol/kg dry solids; p less than 0.05), whereas the rate constants for sodium efflux were not significantly reduced. There was no difference between the two groups in cell potassium values. The increase in leucocyte sodium content in the presence of normal rate constants for sodium efflux suggests an increase in membrane permeability to sodium, which might be important in the pathogenesis of essential hypertension.

Adult↗
PubMed1980

Leucocyte electrolytes and sodium efflux rate constants in the hypertension of pre-eclampsia.

1. Leucocyte electrolytes were measured in pre-eclampsia and comparison was made with leucocytes from normal primigravidae and from the original pre-eclamptic subjects 6 months after delivery when blood pressure had returned to normal. 2. In pre-eclamptic subjects, leucocyte sodium was elevated and potassium depressed, and the rate constant for sodium efflux was depressed. 3. These changes returned to normal after delivery. 4. An increase in cellular sodium as a result of altered sodium pump activity may be the cause of hypertension in pre-eclampsia.

Female↗
PubMed1977

Excretion of salt and water by patients with sickle-cell anaemia: effect of a diuretic and solute diuresis.

1. Patients with sickle-cell anaemia were unable to increase free water reabsorption (TcH2O) in response to intravenous hypertonic sodium chloride solution. 2. Ethacrynic acid caused a brisk natriuresis in patients with sickle-cell anaemia but fractional sodium excretion was lower in these patients. 3. These findings could be explained by abnormal function of the loop of Henle.

Adult↗
PubMed1975

Effects of hypoxia and histamine infusion on lung blood volume.

Using an isolated perfused cat lung preparation we examined the effects of hypoxia and histamine infusion on the lung blood volume. Total lung blood volume was determined from the indocyanine green transit time and the ether bolus technique was used to estimate arterial and venous volumes during forward and retrograde perfusion, respectively. Changes in lung total fluid content were determined from changes in the blood volume of the perfusion system. Hypoxia increased perfusion pressure and decreased total fluid and blood volume. Histamine infusion also increased perfusion pressure and decreased blood volume. However, histamine increased total fluid volume, indicating an increase in vascular permeability. Hypoxia decreased arterial and venous volumes, and histamine decreased venous volume. The slopes of the arterial and venous volume/pressure curves were not altered by hypoxia or histamine.

Animals↗
PubMedDate not supplied

Prevalence of diabetes and impaired glucose tolerance in Nigerians, Jamaicans and US blacks.

The prevalence of type 2 diabetes, impaired glucose tolerance and associated risk factors were compared in sample surveys in Africa and the Caribbean with the Third National Health and Nutrition Survey (NHANES-III) from the United States. A total of 856 Nigerians, 1286 Jamaicans, and 1827 US blacks were included in the study. Body mass index (BMI) increased in a stepwise fashion across the three populations groups, ie, 23 kg/m2 in Nigerians, 26 kg/m2 in Jamaicans, and 28 kg/m2 in US blacks. The corresponding age-adjusted prevalences of type 2 diabetes among persons aged 25-74, were 1%, 12%, 13%. Jamaican women were found to have the same prevalence of type 2 diabetes as US women (14 vs 13%, respectively); mean BMI was likewise very similar (28 kg/m2 in Jamaican and 29 kg/m2 in US women). BMI and waist-to-hip ratio were both associated with type 2 diabetes prevalence. Findings of this study confirm the marked gradient in type 2 diabetes risk among these genetically related populations and suggest that the blacks in the island nations of the Caribbean and the United States are at particularly high risk. Nigerians exhibited remarkably well-preserved glucose tolerance. Understanding the factors that limit the risk of type 2 diabetes in West Africa, beyond relative absence of obesity, would have considerable public health significance.

Adult↗