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Biomedical subjects

T E Goffman

Publications and source records attributed to T E Goffman.

22 records · Page 2Linked to original sources
PubMed1983

Fatal hypereosinophilia with chromosome 15q- in a patient with multiple primary and familial neoplasms.

A man with large-cell carcinoma of the lung, cerebral meningioma, occult adenocarcinoma of the prostate, and follicular adenoma of the thyroid developed symptomatic, rapidly progressive hypereosinophilia with abnormalities of eosinophil ultrastructure and bone marrow karyotype (45,X,15q22-). Although the patient's eosinophilia defied strict classification as idiopathic hypereosinophilic syndrome (HES), simple tumor-associated eosinophilia, or eosinophilic leukemia, it appeared to be incited by the lung cancer and quickly acquired malignant independence. The family had an excess of prostate cancer and lymphoproliferative neoplasms.

Adenocarcinoma↗
PubMed1982

Familial respiratory tract cancer. Opportunities for research and prevention.

Case studies of two families with lung and other respiratory tract cancers were investigated. Consenting family members underwent comprehensive evaluation, including physical examination, routine laboratory studies, pulmonary function testing, sputum cytology analysis, and lymphocyte karyotyping. In both families, the environmental influence of smoking and, to a lesser extent, occupational exposures were evident risks. Both families had members with multiple primary malignant neoplasms and probably radiogenic cancers, suggestive of inherent predisposition to environmentally induced neoplasia. Furthermore, one family had a newly recognized syndrome of limb and dental anomalies, and, independently, two members were carriers of a balanced translocation between chromosomes 13 and 14. Efforts were made to prevent further respiratory cancer deaths, to search for laboratory markers of risk, and to store blood and tissue specimens for assays in development.

Abnormalities, Multiple↗