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Biomedical subjects

T E Kenny

Publications and source records attributed to T E Kenny.

7 recordsLinked to original sources
PubMed1982

Drugs in the aetiology of cancer: a retrospective study.

A retrospective study of the history of drug use in cancer patients, conducted in general practice and involving 972 patients, has suggested that concurrent treatment with barbiturates and benzodiazepines may involve a cancer risk. Concurrent usage of other drugs with barbiturates was investigated because barbiturates have been reported to alter the handling of other drugs by liver microsomes and to interact with chemical carcinogens in experimental animal systems. If the risk has a basis in fact, it may lie behind the recent report of a small cancer risk associated with barbiturate treatment, in a prospective study based on computerized prescription information in a defined population, raising the hope that our finding can be tested in a larger study. A possible risk associated with prolonged treatment with cortisone related drugs could not be excluded. Four per cent of the cancer patients had tumours at sites consistent with reported occupational hazards and a further 4% suspected site-hazard associations. Occupation and smoking did not contribute to the drug associations noted. Entry of cancer patients from general practice gave a true sample of cancer patients in the area, judged by the distributions of age, sex, marital status and cancer site. Choice of controls from consultations for a new complaint resulted in a group showing deviation in the types of patient similar to those reported for consultations in general practice.

Adolescent↗
PubMed1979

Several standard elective operations for duodenal ulcer: ten to 16 year clinical results.

A survey was undertaken of 558 men with duodenal ulcer who had been treated ten to 16 years previously by truncal vagotomy and drainage, truncal vagotomy and antrectomy and subtotal gastrectomy. Of the 558, 65 had died and 111, presumed living, could not be traced, leaving 382 available for assessment. Between 75 and 85% of the traced patients were considered to have an excellent or very good result, which is a slight improvement on the previously published results in this same group of patients at five to eight years follow-up. Some of the side effects of operation had diminished slightly in frequency and there had been no significant increase in the incidence of recurrent ulceration since the previous survey. Anemia was an uncommon finding. As between the various forms of operation, truncal vagotomy and antrectomy and subtotal gastrectomy demonstrated significantly better protection against proven recurrent ulcer than did truncal vagotomy and pyloroplasty (p less than 0.05). Compared with truncal vagotomy and gastroenterostomy, however, the results of both resection operations, though better, did not achieve statistical significance at p - 0.5 level (p less than 0.1). In regard to Visick gradings the resection procedures had better scores, but the differences were not significant at the p - 0.05 level, except for vagotomy and antractomy as compared with vagotomy and pyloroplasty. But it is stressed that in formulating a policy of surgical therapy for duodenal ulcer the greater inherent immediate risks of resection operations need to be borne in mind.

Drainage↗