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Biomedical subjects

T E Lipatova

Publications and source records attributed to T E Lipatova.

At least 19 recordsLinked to original sources
PubMed2006

[Immunology-related aspects of gastroesophageal reflux disease and Barrett's esophagus formation].

The purpose of the research was to study particular features of the cellular immune status and serum cytokines in patients with the gastroesophageal reflux disease (GERD) and Barrett's esophagus. We have examined 70 patients with erosive GERD and 42 patients with Barrett's esophagus. Clinical, endoscopic, morphological and immunological study methods have been used. Distinctions in parameters of the cellular immune status and serum level of Interleukin-4, Interleukin-8, Interleukin-10, tumor necrosis factor-alpha and interferon-gamma in patients with GERD in the dynamics of treatment and patients with Barrett's esophagus were determined.

Adult↗
PubMed2002

[Regeneration of the esophagus epitheliocytes. Evaluation of pariet efficacy in the treatment of patients with reflux esophagitis].

In this paper the information of treatment by Pariet (Rabeprasol) in 20 patients with erosive reflux-esophagitis are represented. On the basis of clinico-endoscopic, morphological and immunohistochemical investigations it was shown, that using Pariet in treatment of the patients with erosive esophagitis the clinical-endoscopic remission, the regression of inflammation and apoptosis processes and proliferative epithelial activity is achieved in more short terms. The results of observation allow to recommend Pariet as a high effective preparation for treatment of the patients with gastroesophagities reflux.

2-Pyridinylmethylsulfinylbenzimidazoles↗
PubMed2002

[Esophageal epithelial cells renewal in evaluation of the pariet efficacy in the treatment of patients with reflux esophagitis].

The article provides the data on 20 patients with erosive reflux esophagitis, who were treated with Pariet (rabeprazole). It was shown on the basis of conducted clinical endoscopic, morphological and immunohistochemical studies that the application of Pariet in treatment of patients with erosive esophagitis contributes to clinical endoscopic remission, regression of inflammatory changes, recovery of apoptosis processes and proliferative activity of esophagus epithelial cells within a shorter period of time. The results of the observation allow recommending Pariet as a highly efficient preparation for treatment of patients with gastroesophageal reflux disease.

2-Pyridinylmethylsulfinylbenzimidazoles↗
PubMed2001

[Morphofunctional characteristics of endocrine gastric cells in chronic biliary pancreatitis].

Clinicoendoscopic morphological and morphofunctional studies in 50 patients with chronic cholecystitis and 50 patients with chronic biliary pancreatitis have demonstrated that morphometric analysis of the antral stomach endocrine cells secreting melatonin, neurotensin and somatostatin can be used in addition to standard laboratory and device methods for differentiation chronic biliary pancreatitis with biliary pathology.

Chronic Disease↗
PubMed1985

[Changes in the supramolecular organization of polyurethaneurea-acylsemicarbasides in the process of their biodestruction].

Using the scanning electron microscope changes in supramolecular organization of polyurethane, (polyurethanecarbamideacylsemicarbasides), having in the main polymer chain foci of tripeptide were studied. They were subjected to proteolytic enzyme action and implanted into animal organisms. It was found that erosive processes going on the polymer plate are essentially similar either under action of proteolytic enzymes or inside a living organism.

Biodegradation, Environmental↗
PubMed1983

Structural peculiarities of block copolyurethanes with peptide links as rigid block extenders.

X-ray crystal analysis was performed on block copolyurethanes with peptide links as rigid block extenders. The increase in peptide link length was shown to improve the microphase separation of flexible and rigid segments. The influence of the isocyanate nature on phase separation conditions in the block copolyurethanes studied was established. The correlation between mechanical and temperature characteristics and peculiarities of the microphase structure was found. The latter seems especially important because of the dependence existing between the biodegradation tendency of the polyurethanes and their supermolecular organization.

Biodegradation, Environmental↗
PubMed1980

[Chemical composition of linear polyurethanes and the rate of their destruction in physiological solution and animal body].

The examinations of biodestruction of segmental polyurethanes from hexamethylene diisocyanate ethylene glycol and polyesters with different chemical composition: polydiethylene glycol succinate, molecular mass 750 (formula A-19), polydiethylene glycol adypates, molecular mass 800 and 1500 (formula A-14 and A-10) were performed employing physico-chemical and histological methods. It was noted that in physiological liquids and animal organisms that polyurethanes containing more polyester bounds, which easily undergo hydrolytic decomposition, had decomposed in higher rate - A-10 > A-19 > A-14. Histological examination revealed the hydrolytic destruction of samples A-19 and A-10 during 24 weeks. However, the rate and biodestruction degree in sample A-10 (especially in ensuring period) was found to be higher than in sample A-19. This appears in its fragmentation and cell activation in connective tissue, surrounding the alloplastic material. These data are consistent to the results of physico-chemical examinations which revealed that sample A-10 after 24 weeks completely loose the durability and the molecular mass diminishes almost four times, while the sample A-19 maintains 37% of durability comparing to initial condition and molecular mass diminishes only two times. Sample A-14 undergoes destruction, at lower degree maintains 50% of durability and its molecular mass diminishes almost two times. The performed examinations show that the changes of ester groups concentration in polyurethanes give the possibility of regulation of the biodegradation rate.

Animals↗
PubMed1979

[Comparative evaluation of biodestruction of polyurethanes synthetized on the basis of simple and complex polyesters].

In model liquids and experimental animals (rats, rabbits) with the aid of physico-mechanical and histological methods (using interferentially polarizating microscopy) a comparative evaluation was made of the biodestruction of polyurethanes from synthetized simple and complex polyesters. The tissue reaction to intra-abdominal, intramuscular and subcutaneous implantation of perforated stripes of A-19 and Nr. 36 polymer was moderate. Two weeks post-operative increased volumetric biodestruction of the polymers was observed. The course was different in various standards and depended upon the chemical structure of the polymers. Taking into account the slight macrophage tissue reaction, in counterdistinction to the significant volumetric biodestruction which envolved the entire width of the polymer strip, it is assumed that the destruction of the investigated polyurethane composition (adhesive KL-3) takes place by hydrolysis 3 to 6 months post-implant.

Animals↗
PubMed1976

Mucopolysaccharide complexes in the fibrous tissue surrounding hydrophilic polymers in subcutaneous implantation.

The biocompatibility of three types of hydrophilic poly-(glycol methacrylate) gels--homogeneous, microporous and macroporous--was investigated in an experimental subcutaneous implantation. The occurrence of mucopolysaccharide complexes formed by both hyaluronic acid and chondroitine sulphates was examined in the fibrous tissue which surrounds the implant and penetrates into it in the case of a macroporous polymer. In an early stage of investigation hyaluronic acid prevails, but with proceeding collagenization the chondroitine sulphate part becomes predominant.

Animals↗
PubMedDate not supplied

[Immobilization of trypsin on polyurethane matrix].

A method is developed to bind trypsin with the polyurethane matrix. At the first stage the reaction between trypsin and toluylendiisocyanate (TD1) was performed. At the second stage polyisocyanate obtained on the base of TDI-trypsin was sewn with polyoxypropylene glycol with a molecular weight of 1500. 2,4,6-Tris(dimethylaminomethyl)phenol served as an accelerator of the reaction. The polymer obtained is fine-porous and high-elastic. The chemical interaction of trypsin with the polymer is confirmed by the method of IR-spectroscopy and a decrease in the amount of free isocyanate groups. It is shown that the enzymic activity of trypsin chemically bound with the polymer is preserved at a room temperature for several months. When the polymeric net is formed from macrodiisocyanate in the presence of trypsin under conditions when the chemical interaction between the polymer and enzyme activity is also preserved, its value in this case being dependent on the relative content of the enzyme in the polymer -- it is higher in the case when the relative content of the enzyme is less, that may indicate the role of the polymer as a heterogenic cocatalyst or activator. The value of the proteolytic activity of the polymer with the chemically added trypsin is practically constant with its washing off in the column for 24h with 0,05 M veronal buffer whereas under these conditions the polymer with "free" trypsin loses completely the enzymic activity.

Binding Sites↗
PubMedDate not supplied

[Activity of proteolytic enzymes in the kidney and blood serum of rabbits during implantation of different polyurethanes].

It is shown that the activity of neutral proteinase both in homogenate and in blood serum increases by the 14th day the D-1 sample being implanted. In the subsequent periods after implantation the enzyme activity in homogenate is the same. Three and six months after implantation the neutral proteinase activity in blood serum decreases as compared to the norm. The activity of acid proteinase in rabbit kidney homogenates lowers by the 90th day after implantation both for the D-1 and for A-10 samples. For the D-1 sample the enzyme activation in blood serum is observed by the 30th day after implantation, three months later it falls to reach the normal level in 6-12 months and inhibition activity on the 30th day after implantation on the A-10 sample. Such changes in the activity of enzymes in homogenates and blood serum may reflect certain stages of polyurethane biodestruction participation of various enzymic systems of the organism in these processes.

Animals↗
PubMedDate not supplied

[Biodegradable co-polymers of amino acids and synthetic polymers].

The methods of synthesis and properties of copolymers of natural amino acids and of oligopeptides with synthetic polymers are considered as well as their liability to biodestruction processes both under the effect of proteolytic enzymes in vitro and under conditions of the implantation to animals. Such copolymers may be successfully used in biology and medicine as a material for manufacturing temporal endoprostheses, carriers of medicinal preparations, immobilization of biologically active compounds as well as in studies of the mechanism of their action.

Amino Acids↗
PubMedDate not supplied

[Enzymic segregation of segmented polyurethanes containing sugar residues in the composition of the main chain].

It is shown that segmented polyurethanes with D-lactose and D-maltose residues in the main polymer chain are subjected to a specific effect of enzymes: beta-galactosidase and alpha-amylase, respectively. This leads to a decrease in values of characteristic viscosity and physicomechanical indices of polyurethanes after their incubation with the mentioned enzymes. The compounds obtained are subjected to acid hydrolysis, which confirms sugar residues in the main polymer chain.

Animals↗