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T Erb

Publications and source records attributed to T Erb.

27 records · Page 2Linked to original sources
PubMed1996

[Local infiltration of epinephrine and bupivacaine before tonsillectomy].

The effects of peritonsillar injections of epinephrine and local anesthetics before tonsillectomy on blood loss and postoperative pain were evaluated in a prospective, randomized double-blind trial on 103 children. Patients were randomly assigned into one of three groups: controls given injections of 0.9% NaCl (n = 34), patients injected with 0.4 ml/kg (1:200,000) epinephrine combined with 0.25% bupivacaine (n = 33) and patients given only 1:200,000 epinephrine (n = 36). All injections and operations were performed by the same surgeon (KS). Blood loss was calculated by weighing all blood aspirated perioperatively and swabs used during surgery. Postoperative pain was assessed at regular intervals by using three methods: (1) use of a visual analogue scale by parents and nurses to estimate pain; (2) postoperative need for nalbuphine as analgesic; (3) the Hannallah-Broadman semi-objective pain score (including crying, anxiety, restlessness, and changes in blood pressure). The mean blood loss in the control group (given NaCl) was 132 g, which was significantly increased when compared with the epinephrine/bupivacaine group (85 g) and the group treated with only epinephrine (90 g). However, analysis of the postoperative pain scores did not reveal any significant differences among groups. These findings indicate that the peritonsillar injection of bupivacaine does not decrease postoperative pain, but peritonsillar injections of epinephrine will significantly reduce blood loss during tonsillectomy.

Adenoidectomy↗
PubMed1996

Intravenous sedation for retrobulbar injection and eye surgery: diazepam and/or propofol?

Principle goals of sedation for eye surgery are to provide patient comfort and to allow the patient to stay calm during both retrobulbar injection and surgery. Insufficient sedation may not prevent the patient from moving during retrobulbar injection, whereas very deep sedation may result in respiratory complications during surgery. The aim of the present study was to evaluate the effectiveness and suitability of a combination of diazepam and propofol for sedation for both application of retrobulbar block and subsequent elective eye surgery. One-hundred and fifty patients were randomly allocated to receive either diazepam, propofol or a combination of both drugs before retrobulbar injection. Tolerance of retrobulbar injection and comfort during the surgical procedure were assessed by comfort scores using a nominal analogue scale between 1 (worst possible condition) and 6 (best conceivable condition). Side effects related to sedation were recorded. The combination of diazepam and propofol resulted in the highest comfort scores for both retrobulbar block (5.3 +/- 0.3) and the surgical procedure (5.4 +/- 0.4). Diazepam alone did not produce adequate sedation for retrobulbar block (3.1 +/- 0.3), whereas comfort scores during surgery were significantly higher (5.3 +/- 0.3) compared to propofol alone (3.6 +/- 0.4). No severe side effects induced by sedation were noted in any of the study groups. The combination of diazepam and propofol proved able to provide a reliable degree of sedation with minimal side effects for both retrobulbar block and surgery. The combination was clearly superior to the sedation induced by propofol or diazepam alone.

Adult↗
PubMed1988

Human growth hormone in urine: development of an ultrasensitive radiometric assay.

An immunoradiometric assay for human growth hormone (HGH) has been developed which has a detection limit of 1 ng/l and can measure HGH in unextracted urine from normal children and adults. The assay is based on a two-step procedure, using a solid-phase goat-anti-HGH immunosorbent for immunoextraction and [125I]-labeled monoclonal HGH-antibody for detection and quantification. The assay is not affected by urea, NaCl or changes of pH from 5-8. The mean urine HGH concentration in normal children is 6.78 +/- 7.6 (SD) pg/ml, in patients with HGH-deficiency 1.3 +/- 0.9 pg/ml which increases to 11.7 +/- 13.4 pg/ml on the day of growth hormone injection.

Evaluation Studies as Topic↗
PubMed1987

Growth hormone in urine: development of an ultrasensitive assay applicable to plasma and urine.

A radiometric assay for human growth hormone (HGH) was developed based on a polyclonal goat anti-HGH antiserum covalently coupled to nonsedimenting polyacrylamide particles. HGH can be specifically immunoextracted from sample volumes of up to 10 ml. Subsequently, bound HGH is identified and quantitatively measured by a 125I-labelled monoclonal anti-HGH antibody. The assay is insensitive to plasma proteins from 10 to greater than 90%, to changing NaCl and urea molarities and to pH ranges from 6 to 8. The sensitivity in the second incubation is 2 pg/tube, corresponding to a maximum sensitivity of 300 fg/ml of a sample volume of 10 ml (urine) or of 40 pg/ml, if a volume of 50 microliter (plasma) is assayed. In healthy children, a mean HGH excretion of 6.5 ng/24 h was found with a large interindividual range from undetectable to 37.4 ng. An important intraindividual night-to-night variation of HGH excretion was found in several subsequent first morning void samples in healthy children. The mean excretion in 13 HGH-deficient children was 0.9 ng/24 h off therapy and increased to a mean of 6.9 ng/24 h on therapy. In acromegalic patients, the excreted HGH amounted to 73-208 ng/24 h. Preliminary results suggest that the ultrasensitive assay applied to plasma and urine could be a considerable improvement of diagnosis and follow-up of disorders of HGH secretion.

Adolescent↗
PubMed1986

[Relation between long-term artificial respiration and respiratory tract infection in 104 patients in a surgical intensive care unit].

The authors studied over a period of two years prospective connections between long-term artificial respiration and infections of the lower respiratory tract. A distinction was made between colonisation (RTC) and infection (RTI). Besides the incidence rate of RTC and RTI the severity of the infection was recorded. The connections between the underlying disease, the duration of artificial respiration, the age of the patient and the antibiotic treatment with the pathogenesis of RTC and RTI were studied. In more than half of the patients RTC could be demonstrated already within the first 24 hours; differences were related to underlying disease, start of ventilation and antibiotic treatment. The RTI incidence rate in all 104 ventilated patients was 67.3%. 19.2% of these already had RTI when respiration was initiated. Thus 48.1% of the patients developed RTI during artificial respiration. The diagnosis RTI was most frequent on the fourth day of respiration, and 80% of all RTI cases had appeared by the fifth day. The highest incidence was seen in patients with a thoracic trauma (85.7%). This group of patients also included the majority of life threatening cases of RTI. In one-quarter of the patients who developed RTI during artificial respiration there was no significant deterioration of pulmonary gas exchange; in 56% however, respiration was impaired to a life-threatening extent. The age of the patients did not have any bearing on the incidence rate and severity of RTI; however, all patients under artificial respiration who were over 70 years of age, died if the severity of the RTI had to be classified as life-threatening.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗