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Biomedical subjects

T F Gray

Publications and source records attributed to T F Gray.

4 recordsLinked to original sources
PubMed1994

Current status of peripheral blood progenitor cell transplantation.

Peripheral blood hematopoietic progenitor cells are primitive cells capable of both self-renewal and terminal differentiation. Cells can be collected in large numbers from the peripheral blood following their stimulation by cytokine administration or during the hematologic recovery phase following chemotherapy administration. Following their collection from the peripheral blood, these cells have been used both as a supplement and an alternative to bone marrow in providing hematologic reconstitution following high-dose chemotherapy and/or radiation. This article describes the biology of these cells, reviews current methods for their acquisition, and discusses the clinical applications in which they have been found useful.

Animals↗
PubMed1992

Relation between systemic hypertension and pain perception.

To test the hypothesis that hypertension diminishes pain perception, a study was made that evaluated the relation between arterial blood pressure and thermal pain perception in human subjects. The average mean arterial pressure in all 20 men studied (10 hypertensive, 10 normotensive) proved to be significantly related to both thermal pain threshold (p = 0.05) and tolerance (p = 0.003). The difference between normotensive and hypertensive groups in baseline and posttest plasma levels of beta endorphin was also significant (p = 0.02) and indicated an interaction between endogenous opioids and blood pressure. Other recent studies of hypertension in relation to hypalgesia were also reviewed. An increased pain threshold was found in hypertensive versus normotensive rats. In cats, electrical stimulation of vagal afferent nerves (cardiopulmonary baroreceptors) suppresses nociceptive responses, and both pharmacologic elevation of blood pressure and vascular volume expansion produce antinociception. Together with preliminary findings in human studies, these results indicate an interaction between pain-controlling and cardiovascular regulatory functions that is probably mediated by the baroreceptor system.

Adult↗
PubMedDate not supplied

Ability of hearing-impaired listeners to understand connected discourse.

Thirty-three hearing-impaired listeners estimated the intelligibility of connected discourse presented in quiet and in the presence of noise. Speech-understanding scores were compared to routine audiometric measures and the effects of both signal-to-noise ratio and level of amplification upon speech understanding were investigated. The listeners were able to estimate the intelligibility of connected discourse reliably. Measures of auditory sensitivity were correlated highly with percentage of understanding only when connected discourse was presented at a low level and a favorable signal-to-noise ratio. The relationship of routine measures and speech understanding was low. A method for obtaining estimates of the intelligibility of running speech is presented along with the results for a typical audiology clinic population.

Adult↗