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Biomedical subjects

T F Loh

Publications and source records attributed to T F Loh.

At least 19 recordsLinked to original sources

A preliminary report on ABO incompatible bone marrow transplant.

Between September 1985 and June 1990, five patients with major and six patients with minor ABO blood group incompatibility between donor and recipient underwent allogeneic bone marrow transplantation (BMT) in the Singapore General Hospital. The period to engraftment, rate of recovery of peripheral blood leukocytes, granulocytes, and platelets and the incidence of graft versus host disease (GVHD) was similar to that observed following ABO blood group compatible marrow transplant. Erythroid development and reticulocytosis were, however, significantly delayed in patients receiving major ABO incompatible marrow transplant.

ABO Blood-Group System

Individualised treatment of seven cases of acquired factor VIII inhibitors.

Seven non-haemophilic patients with acquired Factor VIII inhibitors, admitted to Singapore General Hospital from 1986 to 1990, were studied to analyse their characteristic clinical features and therapeutic outcome. They all had low Factor VIIIC activities, ranged from 0 to 7% and their Factor VIII inhibitors ranged from 1.5 to 128 Bethesda units. All were Chinese aged 30 to 66 years, median 49 years. Six were females, with only one male. Five had associated autoimmune diseases and two had no apparent underlying disorder. One out of seven patients died despite treatment. Therapeutic approach is largely individualised. It may be life-threatening and needs prompt and adequate treatment.

Acute Disease

Cystinuria.

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Amino Acids