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T F Murray

Publications and source records attributed to T F Murray.

112 records · Page 7Linked to original sources

Pharmacological and behavioral components of tolerance to LSD and mescaline in rats.

A fixed-ratio schedule of water reinforcement (FR-10) was used to examine the relative contributions of pharmacological and behavioral mechanisms in the development of tolerance to the disruptive effects of LSD and mescaline in the rat. Rats treated daily with LSD or mescaline before operant testing developed tolerance to the impairement of responding, while rats treated daily after each session did not display tolerance when the drugs were administered before testing. These results indicate that behavioral compensatory mechanisms may be involved in the development of tolerance to the disruptive effects of LSD and mescaline on fixed-ratio (FR-10) performance.

Animals↗

Levonantradol-induced inhibition of acetylcholine turnover in rat hippocampus and striatum.

The effects of levonantradol, a structural novel cannabinoid-related analgesic, on the turnover rate of acetylcholine (TRACh) have been studied in various regions of the rat brain. Levonantradol (0.3 mg/kg subcutaneously) decreases the tRACh in the hippocampus and striatum by 53 and 30 per cent, respectively. The extent of the reduction in TRACh is dose dependent, with a maximal decrease of 80 per cent in the hippocampus and 57 per cent in the striatum following the 3 mg/kg dose. In contrast, cortical TRACh is not affected by any dose of levonantradol. This pattern of activity on cholinergic dynamics elicited by levonantradol is qualitatively similar to that of cannabinoids but differs from that previously reported for narcotic analgesics. Moreover naltrexone (2 mg/kg intraperitoneally) does not reverse the effects of levonantradol on striatal or hippocampal TRACh. This pattern of activity on cholinergic dynamics elicited by levonantradol is consistent with a cannabinoid-like rather than an opioid-like mode of action.

Acetylcholine↗

Axial and lateral radiographs in evaluating patellofemoral malalignment.

This is a prospective study of 431 patients (862 knees) with patellofemoral pain, patellar dislocation, or other abnormalities of the knee joint. There were 217 asymptomatic knees with no contralateral problems for comparison. All patients had a history and physical and radiographic examination of both knees. The radiographs included standard anteroposterior views, axial views at 30 degrees of knee flexion, and standing lateral views at 0 degree and 30 degrees of flexion. The presence of patellar tilt or subluxation was noted on the axial view. The lateral view of the patella, with precise overlap of the posterior femoral condyles, allowed determination of relationships between the patella's medial edge, median ridge, and lateral edge to assess patellar tilt. Sixty-two percent of patients with patellar dislocations demonstrated subluxation on the axial view, while 98% demonstrated an abnormal lateral view. Eighteen percent of the control knees revealed evidence of subluxation on the axial view while 35% demonstrated subluxation on the extended lateral view. The axial view demonstrated 62% sensitivity for dislocation, while the lateral view taken in full extension demonstrated 98% sensitivity. The specificity for previous dislocation was 82% for the axial view and 93% for the lateral flexed view. Given the high sensitivity of the lateral view for detecting prior patellar dislocation, a normal result on this view can virtually eliminate the question of previous dislocation. Also, with the high specificity of the axial view and lateral view with knee flexion, the two views combined can confirm a clinical impression of patellofemoral malalignment.

Adolescent↗