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T FRANCIS

Publications and source records attributed to T FRANCIS.

At least 19 recordsLinked to original sources

FURTHER OBSERVATIONS ON THE RELEVANCE OF SEROLOGIC RECAPITULATIONS OF HUMAN INFECTION WITH INFLUENZA VIRUSES.

By use of a photometric method which objectively distinguishes between homologous and heterologous antibody reactions, the age distribution of specifically reacting swine and Asian antibodies present in sera of persons not recently exposed to either virus was established. The findings support the thesis that the unique distribution by age of swine and Asian antibodies recognizes two past periods of prevalence of swine and Asian-like viruses, respectively. The findings apparently refute the conclusion that the existence of age-specific Asian and swine antibody patterns is primarily attributable to the undirected or passive accumulation of experience with Asian or swine antigens present as minor antigenic components in most strains of influenza A.

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A study in vitro of components in the transmission cycle of swine influenza virus.

Swine lungworm extracts and suspensions of swine lungworms contain receptor-like substances capable of adsorbing influenza virus, a result consonant with the hypothesis (5-8) that the lungworm may be involved in the swine influenza cycle. Yet no evidence for multiplication of virus or even persistence of infectious virus in lungworms at undimished titer was found. Clearly much more information is needed, and it is hoped that the present demonstration of the practicality of studying the components of the transmission cycle proposed by Shope, will provide important tools requisite for further investigation of this problem. Studies on the role of the earthworm in the transmission of swine influenza suggest that, at best, that role would be a passive one.

Animals↗