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Biomedical subjects

T Fainstat

Publications and source records attributed to T Fainstat.

14 recordsLinked to original sources
PubMed1988

Major congenital anomalies in infants and glycosylated hemoglobin levels in insulin-requiring diabetic mothers.

Glycosylated hemoglobin levels were obtained in 133 diabetic pregnancies. Nongestational diabetic mothers delivered of infants with major congenital anomalies had significantly higher glycosylated hemoglobin levels than the remaining nongestational diabetic mothers (P less than .001). The higher a mother's glycosylated hemoglobin level, the higher her risk of having a severely affected infant was. The positive predictive value for a nongestational diabetic mother having an infant with severe congenital anomalies was 26% if the glycosylated hemoglobin level was greater than or equal to 11%, 40% if the level was greater than or equal to 12%, and 56% if the level greater than or equal to 13%. However, high glycosylated hemoglobin levels in insulin-requiring gestational diabetic mothers were not predictive of major congenital anomalies.

Congenital Abnormalities↗
PubMed1986

Perinatal events and cerebral palsy.

This review highlights recent studies that refute the following hypothesis on the genesis of cerebral palsy: The risk factors that cause death are also risk factors for brain damage resulting in cerebral palsy, if they occur at lower intensity, less frequently, or for a shorter duration. Untested, unproved, and invalid theories that emerged in the 1950s stimulated the assembly of much data that are at odds with the notion that the pathways of causation for cerebral palsy and perinatal mortality are identical.

Acidosis↗
PubMed1979

Corpus luteum dysfunction: serum progesterone levels in diagnosis and assessment of therapy for recurrent and threatened abortion.

These studies were designed to show that properly timed measurements of serum progesterone (P) can be conveniently used in the diagnosis and treatment of patients with recurrent and threatened abortion. Luteal phase serum P levels between 2 and 10 ng/ml and serum P levels below 15 ng/ml in the first 10 weeks of gestation were considered diagnostic of corpus luteum (CL) dysfunction. Patients were treated with clomiphene, gonadotropins, and/or progesterone suppositories in order to correct serum P levels, thus elevating the serum P into the normal range. When treatment of patients with subnormal P levels resulted in normalization of serum P, successful pregnancies occurred. CL dysfunctions, either before or after conception, were found in eight of the nine patients with histories of recurrent spontaneous abortions. Correction of serum P was associated with successful pregnancy in these eight patients. Twelve patients with threatened abortion were also found to have subnormal serum P levels. Progesterone suppositories corrected the serum P levels in nine of the eleven patients treated, and none of these patients aborted. Serum P measurements provide a means for evaluation of CL function during early gestation. Management of patients with CL dysfunction can also be monitored with serial serum P measurements, provided that progesterone is the therapeutic agent rather than synthetic progestins.

Abortion, Habitual↗
PubMed1976

In vitro ovulation from adult hamster ovary.

The purpose of the study was to achieve in vitro ovulation in order to acquire corpora lutea in vitro at "time zero" of their formation. Such in vitro corpora lutea would later be the subject of studies on maintenance and lysis of corpora lutea in vitro. Ovaries from adult hamsters, explained into chemically defined medium between 23:00 hours on the day of proestrus and 01:00 hours on the day of estrus, were examined in the culture medium at 10:00 hours on the day of estrus i.e., after 9 to 12 hours of incubation. Ovulated follicles (young corpora lutea) of differing stages of corpus luteum formation were observed in some of the explants, but not at all. Almost all ovulated ova, surrounded by their cumuli oophori, remained adherent to the area of rupture when the incubation was ended. In vitro ovulation occurs in chemically defined medium without added hormones. It is possible to obtain corpora lutea in vitro at "time zero" of their formation.

Animals↗