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Biomedical subjects

T Fehér

Publications and source records attributed to T Fehér.

At least 19 recordsLinked to original sources
PubMed1992

Serum progesterone, oestrone and oestradiol in pregnant and non-pregnant red deer hinds.

Changes in serum progesterone (P), oestrone (E1) and oestradiol (E2) concentrations were monitored in 34 female red deer (Cervus elaphus) shortly after the end of the breeding season and at mid-gestation. Pregnancy could be detected on the basis of serum P, but there were no significant differences between the pregnant and non-pregnant animals farmed animals in E1 and E2 concentrations. Twenty-five pregnant hinds captured in winter showed serum P levels similar to those found in farmed deer during the gestation period.

Animals↗
PubMed1991

[Dehydroepiandrosterone and dehydroepiandrosterone-sulfate content of the amniotic fluid].

Steroid hormone determinations have been performed in amniotic fluid obtained by amniocentesis in 16 to 20 weeks of pregnancy utilizing our radioimmunological methods. Sporadic estimations reported in the literature were completed with our results of dehydroepiandrosterone (D) and dehydroepiandrosterone sulphate (DS) measurements obtained in relatively great number of cases. The observations allowed the early diagnosis of placental sulphatase deficiency. Study of this enzymopathy suggested that, in addition to oestrogens and progesterone, D and DS may have per se biological-hormonal effects for maturation processes in the intrauterine life. Furthermore, a hypothesis has been outlined for prenatal differential diagnostics of the congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency.

Amniocentesis↗
PubMed1990

Hormonal regulation of complement biosynthesis in human cell lines--I. Androgens and gamma-interferon stimulate the biosynthesis and gene expression of C1 inhibitor in human cell lines U937 and HepG2.

C1 inhibitor (C1inh), a member of the serine protease inhibitor gene superfamily, is a glycosylated plasma protein inhibiting the proteolytic activities of C1r and C1s and involved in the regulation of coagulation, fibrinolysis and kinin-releasing systems. In this study, the in vitro effect of androgen hormones, dehydroepiandrosterone (DHEA), testosterone (TEST) and recombinant human gamma-interferon (gamma-IFN), has been determined on the production of C1inh in human cell lines. In both human monocytoid/histiocytoid cell line U937 and in hepatoma derived cell line HepG2, DHEA and TEST upregulated the gene expression and secretion of C1inh. The most pronounced effect was detected in the concn range 10(-7)-10(-9) M of the hormones. Under the same conditions DHEA and TEST had no detectable effect on the biosynthesis of C3, C2 and factor B by these cells, but DHEA at higher concn (10(-4) M) slightly increased that of C4 in HepG2 cells. Both in U937 and in HepG2 cells recombinant gamma-IFN markedly increased the gene expression and secretion of C1inh. This effect of gamma-IFN was abolished by histamine.

Carcinoma, Hepatocellular↗
PubMed1989

[Testosterone-dihydrotestosterone ratio in the differential diagnosis of pancreatic disease].

Serum testosterone (T), dihydrotestosterone (DT) and androstendione (AD) concentration were determined in male patients with pancreatic cancer (n = 14), chronic pancreatitis (n = 26), other malignancies of the gastrointestinal tract (n = 19) and in control subjects (n = 16). The T level was decreased in patients with pancreatic cancer relative to other groups of patients but the difference was not statistically significant. The T/DT ratio was significantly lower in pancreatic cancer (2.5 +/- 1.0) compared to chronic pancreatitis (9.6 +/- 2.3, p 0.01). The specificity of the ratio is 84%, while the sensitivity was found to be 92%. The discriminative value was found to be 4. The T/DT ratio seems to be a valuable marker in the differentiation of pancreatic cancer from chronic pancreatitis.

Diagnosis, Differential↗
PubMed1987

Serum steroid hormone levels in systemic lupus erythematosus (SLE).

Dehydroepiandrosterone (D), D sulphate (DS), testosterone (T) and oestradiol (OE2) were determined by radioimmunoassay; cortisol (F) by a spectrofluorimetric method in the serum of 54 female patients with SLE. The values were evaluated in two age groups (32 patients with active ovarian function and 22 in menopause). The serum cortisol, T and DS levels were decreased, and there was no difference in that of free (unconjugated) D and OE2 concentrations compared to normal female subjects.

Adolescent↗
PubMed1987

Influence of hormonal imprinting on hormone level. Permanent receptor damaging effect of pituitary hormones administered to newly-hatched cockerels.

The overlapping effect of TSH and FSH on the gonad and on the thyroid gland can be demonstrated in cockerels even at the age of five weeks. These hormones influence the secretion of testosterone in a similar way and to a similar extent, while on the thyroxine level the influence of the specific hormone is more pronounced. Neonatal FSH and TSH treatment considerably decreased the basal testosterone level measured at the age of five weeks. Neonatal FSH treatment increased the basal T4 level while TSH treatment decreased it. The effect of TSH treatment administered at the age of five weeks in increasing the testosterone level was weakened after neonatal pretreatment with any iodine hormone. The effect of TSH treatment could only be inhibited by neonatal FSH pretreatment. Neonatal pretreatment with any of the trophormones caused a diminution of the T4 level augmenting of FSH and TSH administered at the age of five weeks.

Animals↗
PubMed1986

Interrelationship between the immunological and steroid hormone parameters in rheumatoid arthritis.

In the present work the correlation between the immunological parameters and plasma androgen hormone levels in rheumatoid arthritis (RA) was examined. Female patients were divided in groups according to their age and immunologic state. Plasma dehydroepiandrosterone (D), D sulphate (DS), and testosterone (T) levels were determined by radioimmunological methods. The values were related first to those of normal controls. The T and DS levels were significantly decreased in all patient groups examined, the D level was low only in "Rf+ active" state aged 18 to 45 years. Furthermore, it was examined whether the decreased hormone levels were in relationship either with the autoantibody (Rf) formation or with the activity of the disease. According to the observations the T levels were influenced neither by the autoantibody formation nor by the activity of the disease. The DS and D levels appeared to correlate both with the autoantibody formation and the activity of the disease, particularly in young patients, being significantly low in the "Rf+ active" state. From these we concluded that the condition of the immune system has an influence on the sex hormone and/or adrenal androgen function.

Adolescent↗
PubMed1986

Androgens, bone mineral content and hyperostosis frontalis interna in pre-menopausal women.

Greater than normal bone mineral content, bone width of the radius measured by photon absorptiometry and bone mineral content to bone width ratio found in women with hyperostosis frontalis interna pointed on a generalized alteration of the skeletal system. An increase in serum dehydroepiandosterone, its sulphate and testosterone levels and a significant correlation between serum free dehydroepiandosterone and bone mineral content in subjects without any sign of hirsutism or obesity suggested an involvement of androgens in pathogenesis of this metabolic bone disorder.

17-alpha-Hydroxyprogesterone↗
PubMed1986

Effect of vitamin D3 loading and thyroid hormone replacement therapy on the decreased serum 25-hydroxyvitamin D level in patients with hypothyroidism.

Twelve hypothyroid subjects, 13 healthy and 12 healthy women with a slight deficiency of vitamin D were studied to distinguish seasonal changes from the thyroxine-dependent ones. Serum 25-hydroxyvitamin D levels of hypothyroid patients were lower than those of healthy individuals when the sera were obtained in the autumn. In hypothyroid patients a single oral dose of 100,000 IU vitamin D3 resulted in a smaller increase in 25-hydroxyvitamin D concentration than in controls having subclinical exogenous vitamin D deficiency. Substitution therapy with thyroid hormone, started in our study always in autumn, increased the 25-hydroxyvitamin D concentration in hypothyroid patients, which was opposite to the autumn-to-spring variation of this hormone observed in healthy controls. The increase of 25-hydroxyvitamin D, dehydroepiandrosterone and its sulphate values following substitution therapy in the hypothyroid patients may indicate that thyroid hormone(s) is (are) involved in the regulation of steroid hormone synthesis.

Adolescent↗
PubMed1986

High serum bile acid level in obesity: its decrease during and after total fasting.

Elevated serum bile acid levels were observed in overweight subjects as compared to those with an ideal weight. Fasting for 14 days resulted in a gradual decrease to the normal level of serum cholic, chenodeoxycholic and deoxycholic acid concentrations. There was no change in the serum bile acid level during a two days refeeding period. The findings suggest that, in addition to the beneficial weight reduction, normalization of bile acid homeostasis can be achieved by fasting in obesity.

Adult↗
PubMed1986

Alterations in the number of glucocorticoid receptors of circulating lymphocytes in sepsis.

A 2-to 16-fold increase in the number of glucocorticoid receptors of circulating lymphocytes was observed in 17 septic patients as compared to 10 control patients with no inflammatory disease. The number of receptors was low in 3 septic patients who did not respond to antibiotic and glucocorticoid therapy and died. Intravenous administration of 100 mg of cortisol reduced the number of receptors available to the assay by about 30% in both septic and control patients.

Adult↗
PubMed1985

Effect of ACTH and prolactin on dehydroepiandrosterone, its sulfate ester and cortisol production by normal and tumorous human adrenocortical cells.

The effect of ACTH and prolactin on the synthesis of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) was studied in cell suspensions of "normal" and tumorous (adenoma) human adrenal cortex. A stimulation of DHEA and no response of DHEAS production by ACTH in "normal" adrenocortical cell suspension was observed. However ACTH stimulated both DHEA and DHEAS synthesis in tumorous adrenocortical cells. Prolactin did not influence either the basal or the ACTH stimulated DHEA and DHEAS production of adrenocortical cells irrespective of their origin. Our results are compatible with the concept that the biosynthesis of DHEA is under ACTH control, while other factor(s) regulate(s) the sulfate pathway of DHEA secretion under normal conditions. In tumorous adrenocortical cells DHEA may be regulated--at least partly--by ACTH. Prolactin seems to have no direct effect on DHEA and DHEAS synthesis. It is postulated that the relationship between serum prolactin and DHEAS (or DHEA) levels observed by several authors might be an extraadrenal effect of prolactin on adrenal androgens.

Adrenal Cortex↗