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Biomedical subjects

T Field

Publications and source records attributed to T Field.

At least 19 recordsLinked to original sources

Clinical and laboratory features of patients with scleroderma and silicone implants.

We reviewed the available clinical and laboratory data from 56 patients with scleroderma and silicone implants from the English medical literature and 19 cases which have not been previously reported. The average age of onset of scleroderma was 43.6 +/- 10 years (range 20-73). Patients had silicone implants for an average of 9 +/- 4 years prior to the development of scleroderma (range 1-32). Most patients had limited scleroderma (41%). Twenty three percent had intermediate scleroderma and 36% had diffuse scleroderma. Clinical findings included: Raynaud's phenomenon in 77%, esophageal dysfunction in 53%, and pulmonary involvement in 47%. Cardiac and renal involvement were uncommon. Antinuclear antibodies by immunofluorescence were found in 83 percent of patients. The immunofluorescence pattern was speckled in 53%, centromere in 31% and nucleolar in 9%. Other antibodies (Scl-70, RNP, SSA/Ro, PM-Scl) were found in only a small proportion of patients. A clinical, serologic and immunogenetic comparison of patients with silicone implants and scleroderma and patients with idiopathic scleroderma is needed to better understand the pathogenesis of this disorder.

Adult

"Depressed" mothers' perceptions of infant vulnerability are related to later development.

Fifty-four depressed and non-depressed mothers were interviewed when their infants were 3 and 12 months of age. The depressed mothers assigned greater vulnerability scores and their infants engaged in less exploratory play and had lower Bayley mental and motor scores. The depressed mothers' vulnerability scores at 3 months were related to less exploratory play in their infants as well as lower Bayley mental scores at 12 months.

Adolescent

Preschoolers of dysphoric mothers.

Dysphoric mothers rated their preschool children as having more internalizing and externalizing behavior problems than children of nondysphoric mothers. Observers rated the dysphoric mothers as having more negative affect during play interactions, although their children's affect was not rated more negatively. The dysphoric mother-infant dyads were also rated as having a poorer quality interaction. These data suggest that mothers' chronic dysphoria (75% were chronically dysphoric) has a negative impact on the mothers' perceptions of their children as well as the mothers' and children's interaction behavior.

Adult

Attachment and separation in young children.

Attachment theory is criticized for being based on momentary stressful situations, for being limited to behaviors and occur with the primary attachment figure, for including only overt behaviors in its paradigm, and for failing to consider multiple attachments at different stages of life. A model of psychological attonement is then presented and supported by several studies documenting behavioral, physiological, and biochemical responses to separations from parents and peers.

Animals

Massage therapy is associated with enhancement of the immune system's cytotoxic capacity.

Twenty-nine gay men (20 HIV+, 9 HIV-) received daily massages for one month. A subset of 11 of the HIV+ subjects served as a within subject control group (one month with and without massages). Major immune findings for the effects of the month of massage included a significant increase in Natural Killer Cell number, Natural Killer Cell Cytotoxicity, soluble CD8, and the cytotoxic subset of CD8 cells. There were no changes in HIV disease progression markers (CD4, CD4/CD8 ratio, Beta-2 microglobulin, neopterin). Major neuroendocrine findings, measured via 24 hour urines included a significant decrease in cortisol, and nonsignificant trends toward decrease of catecholamines. There were also significant decreases in anxiety and increases in relaxation which were significantly correlated with increases in NK cell number. Thus, there appears to be an increase in cytotoxic capacity associated with massage. Implications for HIV+ men as those with other illnesses, particularly cancer, are discussed.

Adult

Under-eating and over-eating concerns among adolescents.

462 adolescents were given a set of scales to determine their concerns about eating (under-eating or over-eating), and perceptions of family and peer intimacy, social support, self-esteem, depression and exercise. Although only 10% stated that they were "underweight" and 21% that they were "overweight", as many as 50% reported having eating concerns. As compared to those who did not have concerns about eating, those who were concerned about undereating felt that they had poorer relationships with their mothers and fathers, less social support, lower self-esteem and low levels of exercise. In contrast, those who were concerned about overeating perceived having an intimacy problem only with their fathers. Like those concerned about undereating, the group concerned about overeating also had lower self-esteem and low levels of exercise. But, unlike the under-eating concern group, the over-eating concern group scored higher on the depression scale.

Adolescent

Mothers touching newborns: a comparison of rooming-in versus minimal contact.

We compared the maternal behaviors of women who had extended and early contact (rooming-in) with their infants with those who had contact only during feedings. Thirty-one young, unmarried, predominantly black, lower-socioeconomic mothers and their infants were observed in the mother's hospital room for 15 minutes after a morning feeding approximately 18 hours after delivery. A time sample unit checklist was used to record each mother's behavior, looking, talking, and touching directed toward their infants and others, as well as watching television and talking on the telephone. Analyses of variance revealed that the rooming-in mothers looked at, talked to, and touched their infants more, watched less television, and talked less on the telephone than mothers with minimal contact with their infants. These findings suggest that increased postpartum contact with infants leads not only to more interaction, but also to more touching as well as touching in more intimate places (face and head), thus highlighting the value of rooming-in arrangements for mothers and infants.

Adolescent

Adolescents' intimacy with parents and friends.

Adolescents' perceived levels of intimacy with their mother, father, and close friend were examined as a function of demographic, family and school, and psychological variables. Students with same-sex friends and greater interest in school reported greater intimacy with their mothers. Students with higher self-esteem, lower depression, and lower risk-taking scores reported greater intimacy with their mothers and fathers. The greatest number of relationships with positive variables involved intimacy with mothers.

Adolescent

Massage therapy for infants and children.

Data are reviewed on the effects of massage therapy on infants and children with various medical conditions. The infants include: premature infants, cocaine-exposed infants, HIV-exposed infants, infants parented by depressed mothers, and full-term infants without medical problems. The childhood conditions include: abuse (sexual and physical), asthma, autism, burns, cancer, developmental delays, dermatitis (psoriasis), diabetes, eating disorders (bulimia), juvenile rheumatoid arthritis, posttraumatic stress disorder, and psychiatric problems. Generally, the massage therapy has resulted in lower anxiety and stress hormones and improved clinical course. Having grandparent volunteers and parents give the therapy enhances their own wellness and provides a cost-effective treatment for the children.

Blood Glucose

"Depressed" mothers' perceptions of their preschool children's vulnerability.

"Depressed" mothers who scored in the depression range on the Beck Depression Inventory when their infants were 3-months-old were asked to complete the Vulnerable Child Scale when their children were preschool age. Depressed versus non-depressed mothers rated their preschool children as being more vulnerable (as did an independent observer) as well as having more behavior problems. The vulnerability ratings were significantly related to infancy stage measures including the POMS (mothers' depressed mood), the infants' behavior ratings and heart rate range during interactions with a nondepressed stranger. These measures of the mothers' and infants' behavior tapped during early infancy may have contributed to the mothers having perceived their children as "vulnerable" during the preschool stage.

Adult

Adolescents' perceptions of their risk-taking behavior.

A questionnaire comprised of several self-report scales was administered to 440 adolescents to assess differences between high and low sports and danger risk takers on relationship and personality variables. Sports risk takers reported more danger-related risk taking and more drug use but higher self-esteem than did nonrisk takers. Danger risk takers reported greater sports-related risk taking and more drug use as well as less intimacy with their mothers, less family responsibility taking, and less depression than did their nonrisk-taking counterparts.

Adolescent

The effects of mother's physical and emotional unavailability on emotion regulation.

In summary, emotion dysregulation can develop from brief or more prolonged separations from the mother as well as from the more disturbing effects of her emotional unavailability, such as occurs when she is depressed. Harmonious interaction with the mother or the primary caregiver (attunement) of the mother's physical unavailability were seen in studies of separations from the mother due to her hospitalization or to her conference trips. These separations affected the infants' play behaviors and sleep patterns. Comparisons between hospitalizations and conference trips, however, suggested that the infants' behaviors were more negatively affected by the hospitalizations than the conference trips. This probably related to these being hospitalizations for the birth of another baby--the infants no longer had the special, exclusive relationship with their mothers after the arrival of the new sibling. This finding highlights the critical importance of emotional availability. The mother had returned from the hospital, but, while she was no longer physically unavailable, she was now emotionally unavailable. Emotional unavailability was investigated in an acute form by comparing two laboratory situations, the still face paradigm and the momentary leave taking. The still face had more negative effects on the infants' interaction behaviors than the physical separation. The most extreme form of emotional unavailability, mother's depression, had the most negative effects. The disorganization or emotion dysregulation in this case is more prolonged. Changes in physiology (heart rate, vagal tone, and cortisol levels), in play behavior, affect, activity level, and sleep organization as well as other regulating functions such as eating and toileting, and even in the immune system persist for the duration of the mother's depression. My colleagues and I have suggested that these changes occur because the infant is being chronically deprived of an important external regulator of stimulation (the mother) and thus fails to develop emotion regulation or organized behavioral and physiological rhythms. Finally, individual differences were discussed, including those related to maturity (e.g., prematurity) and temperament/personality (e.g., uninhibited/inhibited or externalizing/internalizing) and those deriving from degree of mother-infant mismatch, such as dissimilar temperaments. Further investigations are needed to determine how long the effects of such early dysregulation endure, how they affect the infant's long-term development, how their effect differs across individuals and across development, and whether they can be modified by early intervention. Eventually, with increasing age, developing skills, and diversity of experience, infants develop individualized regulatory styles. That process, and how it is affected by the mother's physical and emotional unavailability, also requires further investigation.

Affect

Psychosocial stressors among depressed adolescent mothers.

This study sought to determine whether depressed adolescent mothers experience more psychosocial stressors than do nondepressed mothers and which stressors best predict maternal depression. Subjects consisted of 154 adolescent mothers 14 to 21 years of age who were recruited 1 to 3 days postpartum. The Beck Depression Inventory was used to assess severity of depression, and the Problem Oriented Screening Instrument for Teenagers was administered to assess mothers' level of psychosocial functioning. Depressed mothers consistently reported more problems in most areas of psychosocial functioning. Additionally, the best predictors of maternal depression were mental health status, family relations, and social skills.

Adolescent

Children of methadone-dependent women: developmental outcomes.

A group of 20 children was assessed for possible effects at school age of prenatal exposure to methadone. Compared to a control group of 20 nonexposed children on measures of cognitive, social, and emotional development, and of achievement, no significant differences were found on cognitive tests, although methadone exposure was associated with lower IQ scores. Methadone-exposed children exhibited greater anxiety, aggression, and rejection than did those in the control group, and their mothers reported more behavior problems.

Affective Symptoms

Massage effects on cocaine-exposed preterm neonates.

Thirty preterm cocaine-exposed preterm neonates (mean gestational age 30 wks, mean birth weight = 1212 g, mean intensive care unit duration = 18 days) were randomly assigned to a massage therapy or a control group as soon as they were considered medically stable. Group assignment was based on a random stratification of gestational age, birth weight, intensive care unit duration, and entry weight into the study. The treatment group (N = 15) received massages for three 15-minute periods 3 consecutive hours for a 10-day period. Findings suggested that the massaged infants (1) averaged 28% greater weight gain per day (33 vs 26 g) although the groups did not differ in intake (calories or volume), (2) showed significantly fewer postnatal complications and stress behaviors than did control infants, and (3) demonstrated more mature motor behaviors on the Brazelton examination at the end of the 10-day study period.

Adult

Factors that predict which preterm infants benefit most from massage therapy.

Ninety-three preterm infants (M gestational age = 30 wks; M birth weight = 1204 g; M ICU duration = 15 days) were randomly assigned to a massage therapy group or a control group once they were considered medically stable. The treatment group (N = 50) received three daily 15-minute massages for 10 days. The massage therapy infants gained significantly more weight per day (32 vs 29 g) than did the control infants. Treatment and control groups were divided into high and low weight gainers based on the average weight gain for the control group. Seventy percent of the massage therapy infants were classified as high weight gainers whereas only 40% of the control infants were classified as high weight gainers. Discriminant function analyses determining the characteristics that distinguished the high from the low weight gainers suggested that the control infants who, before the study, consumed more calories and spent less time in Intermediate care gained more weight. In contrast, for the massage therapy group, the pattern of greater caloric intake and more days in Intermediate care before the study period along with more obstetric complications differentiated the high from the low weight gainers, suggesting that the infants who had experienced more complications before the study benefitted more from the massage therapy. These variables accurately predicted 78% of the infants who benefitted significantly from the massage therapy. Thus, these variables can be used to suggest infants who would benefit most from future massage therapy programs.

Birth Weight

Massage reduces anxiety in child and adolescent psychiatric patients.

A 30-minute back massage was given daily for a 5-day period to 52 hospitalized depressed and adjustment disorder children and adolescents. Compared with a control group who viewed relaxing videotapes, the massaged subjects were less depressed and anxious and had lower saliva cortisol levels after the massage. In addition, nurses rated the subjects as being less anxious and more cooperative on the last day of the study, and nighttime sleep increased over this period. Finally, urinary cortisol and norepinephrine levels decreased, but only for the depressed subjects.

Adjustment Disorders

Tactile-kinesthetic stimulation effects on sympathetic and adrenocortical function in preterm infants.

The purpose of our study was to investigate the neuroendocrine response in preterm infants to a pattern of tactile-kinesthetic stimulation that facilitates their growth and development. Preterm infants (mean gestational age 30 weeks, mean birth weight 1176 gm) received normal nursery care or tactile-kinesthetic stimulation for three 15-minute periods at the start of three consecutive hours each day for 10 days. On day 1 and day 10 of the study, a 24-hour urine sample was collected for norepinephrine, epinephrine, dopamine, cortisol, and creatinine assay and a blood sample was taken by heel stick for cortisol and growth hormone assay. Urine norepinephrine and epinephrine values increased significantly only in the stimulated babies. Urine dopamine and cortisol values increased in both groups, and serum growth hormone decreased in both groups. Individual differences in urine norepinephrine, epinephrine, dopamine, and cortisol values were highly stable across the 10 days despite a 10-fold range of values among the infants. The results of this study suggest that tactile-kinesthetic stimulation of preterm infants has fairly specific effects on maturation and/or activity of the sympathetic nervous system. In addition, this study has defined catecholamine and cortisol secretion across gestational age in normal preterm infants. Finally, these data suggest that highly stable individual levels of catecholamine and cortisol secretion are established by birth in humans.

Creatinine