[Chromosome studies in multiple myeloma].
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Biomedical subjects
Publications and source records attributed to T Fleischmann.
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In 15 cases, chromosome studies were performed in short-term lymph node cultures, using the banding technique. Clonal aberrations were found in two cases of Hodgkin's disease and in two of lymphosarcoma. In agreement with earlier observations, the cases of lymphosarcoma with abnormal karyotypes proved hyperdiploid. No chromosomal aberrations were found in three cases of reactive lymphoreticular hyperplasia.
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Chromosome analysis in two cases of acute myeloid leukaemia are reported. On the basis of slight aberrations in the banding pattern marker chromosomes were observed in both cases. In one case a widened C-band of an additional D chromosome, and in the other case an unusual negative fluorescent band below the centromere of one of the chromosomes 16, were seen.
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Chromosomal aberrations in a case of atypic myeloproliferative syndrome are reported. The analysis was carried out on short-term cultures of sternal bone marrow with the ASG and fluorescence method. 90% of the metaphases studied showed pseudoliploidy: one of the chromosomes 12 was missing and one submedian marker chromosome of medium size and atypical morphology appeared.
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