Biomedical subjects

T Frangov

Publications and source records attributed to T Frangov.

11 recordsLinked to original sources

PubMed2004

[Cholangiocellular carcinoma--clinical features and surgical treatment].

UNLABELLED: Cholangiocellular carcinoma is the second on rate primary liver cancer (7-10%), after hepatocellular carcinoma--(80-85%). The aim of this study is to present some diferrencies in clinical and pathological features in comparison to other liver tumors. MATERIALS AND METHODS: In the period 1991-2002 years, 105 patients with primary liver cancer were operated; 9 of them (8.5%) had cholangiocellular carcinoma (CCC). The men were 5, the women--4, and the mean age 51 years. Hepatic resection was performed in 5 patients, in 1--biliary drainage, in 3--explorative laparotomy. RESULTS: Until 30th postoperative day there was no death in resected patients, but one--the drained patient. Morbidity was: ascites, hepatocellular insuficiency, fever. One patient is alive more than 4 years. CONCLUSIONS: Cholangiocarcinoma affects young people, sometimes they are jaundiced; tumours become big, because asymptomatic grow. Hepatic resection remains to be the best therapeutical option in nonjaundiced patients.

Adult↗

PubMed2003

[Anterior approach for major hepatic resection for large liver malignancy].

The large liver cancers in the right lobe are difficult to be resected with conventional approach. We report for 2 cases--43 old year man with cholangiocellular carcinoma and 50-old year woman with metastatic liver tumor from breast cancer, both with diameter of 30 cm, successfully resected using nonconventional "anterior approach". The postoperative period was uneventful. They were discharged from hospital in 10 and 14 days.

Adult↗

PubMed2003

[Postoperative liver failure after hepatic resections for hepatocellular carcinoma].

Postoperative liver failure is a life-threatening complication after hepatic resection. The purpose of this study was to review the liver failure as a result of hepatic resection and to propose strategy for decreasing the risk of its developing. From January 1991 to December 2000 73 patients with primary liver cancer (PLC) were operated and identified in a retrospective database. Seven (13.2%) of resected 53 patients developed postoperative liver failure. There were 4 male and 3 female with mean age 52.3+/-29.2 (from 1 to 78). 3 patients had underlying cirrhosis. Major resections were 5 and minor--2. Mean hemotransfusion was 1012, 13 ml (370-2000 ml). Five patients (71%) died by the 30th day. The causes of liver failure were analyzed, based on both the preoperative data and the intraoperative findings. Significant prognostic factors were the preoperative serum level of bilirubin (p=0.024) and intraoperative hemotransfusion (0.031). The right hemihepatectomy was a prevalent hepatic resection in these patients.

Adolescent↗

PubMed2002

[Results of surgical treatment of primary liver cancer].

Using a single institution experience, the authors examine hepatic resections in treatment of primary liver cancer (PLC), the postoperative complications and mortality. Seventy-three patients were operated on between January 1991 and December 2000 and identified in a retrospective database. They were 53 men and 20 women of mean age 54.6 (from 1 to 78 years). Of the 73 operated patients with PLC, 53 underwent hepatic resection. Two patients had PLC at stage II, 43--stage III, 8--stage IV. 25 (34%) patients had underlying cirrhosis: 14--Child A and 11--Child B. 34 patients underwent major resections and 19--minor resections. 7 patients (13.2%) died of the hepatic resection--by the 30-th day. Mortality among cirrhotic patients was 25% (4 patients). 16 patients had postoperative complications. 6 patients developed liver failure. Hepatic resection is a basic method in treatment of the PLC. The presence of cirrhosis, especially Child B, increases surgical morbidity and mortality.

Adolescent↗

PubMed2002

[Hepatic resections for hepatocellular carcinoma and cirrhosis].

Liver resection in a patient with cirrhosis carries increased risk. The purposes of this study were to review the results of cirrhotic liver resection in the past decade and to propose strategies for low morbidity and mortality. From January 1991 to December 2000 73 patients with primary liver cancer (PLC) were operated and identified in a retrospective database. Twenty five (34%) patients had underlying cirrhosis: 14--Child A and 11--Child B. There were 18 male and 7 female with mean age 60.9 +/- 9.2 (from 44 to 78). There were 16 (64%) resections: 11--stage Child A and 5--stage Child B. Major resections were 7 and minor--9. Eight patients received hemotransfusion--mean 939.13 ml (370-2000 ml). Four patients (25%) died of the hepatic resection--by the 30-th day. Seven patients had postoperative complications. 4 patients developed liver failure. Major resections had 42.86% mortality, minor resections--11.11%. Hepatic resection is potentially curative therapy for HCC and cirrhosis especially in Child A. Child B produce high rate of postoperative morbidity and mortality.

Adult↗

PubMed1998

[Liver resection in a state of normothermic ischemia].

Thirty-three patients undergoing liver resection in a state of normothermic ischemia are described: portal clamping is done in 25 cases at mean duration 41 +/- 8 min, and vascular exclusion of liver--10 cases at mean duration 44 +/- 12 min. This is a procedure accounting for a substantial reduction of intraoperative hemorrhages. In 17 patients hemotransfusion proves unnecessary, while in the remainder the amount of blood transfused averaged 1500 +/- 950 ml.

Adult↗

PubMed1995

[Vascular exclusion during liver resection--an experimental rabbit model].

Vascular exclusion of the liver (VEL) consists in clamping of the portal triad (VCI) below and above the liver. An experimental model of the technique is presented, accomplished in 20 rabbits divided in three groups according to vascular exclusion pattern. Complete VEL reduces the hazards of intraoperative hemorrhage and air embolism during major liver resections.

Animals↗

PubMed1995

[Vascular exclusion of the liver].

Vascular exclusion of the liver (VEL) is a comparatively new and seldom used procedure. It is developed and practically implemented along with liver transplantation, and corresponds to the nonhepatic phase of the latter. VEL reduces considerably the risks of intraoperative hemorrhage, and is indicated in handling large and vascular tumors located in the vicinity of vessels. Its safe duration may reach up to 90 min, and is free of serious postoperative complications. VEL allows for broadening the scope of liver resection, and reduction of intra- and postoperative hemotransfusions.

Hemorrhage↗

PubMed1994

[Diagnostic laparoscopy and laparoscopic surgery--their development and outlook].

Laparoscopy was introduced in the beginning of the 20 century. It is developed as a diagnostic procedure, often combined with biopsy. In the 80 ies the laparoscopy came in surgery, first in appendectomy, later in cholecystectomy, where it achieved exclusive appliance and became an alternative method of conventional surgery. In the beginning of 90-ies the laparoscopic surgery treats more and more of diseases of abdominal surgery.

Abdomen↗

PubMed1993

[Biligenic hepatic and subhepatic abscesses--observations on 9 cases].

This review presents 9 cases with pyogenic hepatic and subhepatic abscesses developed by biliary route. An ultrasonography and computed tomographic scan was performed on 3 patients. Eight patients were treated with open surgical drainage and one with percutaneous drainage under ultrasonic control. All of them received a triple antibiotic therapy. Five patients had diabetes mellitus. Mortality was null.

Adult↗

PubMed1993

[7 cases of liver transplantation with preservation of the vena cava inferior].

Orthotopic liver transplantation (OLT) with preservation of the inferior vena cava (IVC) was performed in 7 patients during a period of 7 weeks. For 5 years in this center are realized 180 OLT, the last 93 of them with preservation VCI (51.6%). This method had important advantages versus standard operation--blood loss and operating time are reduced, IVC does not clamped. This operation can be used in the majority of cases.

Adult↗