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Biomedical subjects

T Fuchs

Publications and source records attributed to T Fuchs.

At least 145 records · Page 8Linked to original sources
PubMed1983

Human leukocyte antigens group A in couples with unexplained infertility.

The human leukocyte antigen (HLA) frequencies and antigen sharing were studied in 14 couples with unexplained infertility. There were no significant differences in the frequency of HLA-A, B, C, or DR antigens, as compared with normal control subjects. Furthermore, the degree of HLA sharing did not deviate from that theoretically expected. An increased frequency of HLA-DR sharing, as compared with the expected frequency, was observed in a control group consisting of parents of children with leukemia. When infertile spouses were tested for mixed lymphocyte culture reactivity, there were no indications of an altered reactivity, as compared with control subjects.

Female↗
PubMed1982

[Clinical importance of sampling method in leucocyturia (author's transl)].

The clinical importance of the method of obtaining a urine sample (spontaneous vs. catheter and midstream specimens) was investigated in 507 in-patients. Whereas leucocyturia was demonstrated with the Cytur-Test on spontaneous urine from 105 patients, only 30 out of 89 of these patients showed leucocyturia in catheter or midstream specimens one to three days later. All 30 positive cases were found to have a disease state which causes leucocyturia. A direct comparison between spontaneous urine and midstream or catheter urine taken at the same time in 68 patients showed a leucocyturia in 20 cases in spontaneous urine which could not be confirmed in the midstream or catheter urine. This drastic difference shows the importance of the method of obtaining specimens in estimating leucocyturia.

Diagnostic Errors↗
PubMed1982

Sex-dependent induction of human suppressor T cells by chorionic gonadotropin.

Human chorionic gonadotropin (hCG) in physiological retroplacental concentration has been shown to induce human female lymphocytes which suppress the proliferation and differentiation of B cells stimulated by purified protein derivative of tuberculin. To test whether the hCG-induced suppression was sex dependent parallel experiments using female and male peripheral lymphocytes were performed. hCG did not induce cells capable of suppressing purified protein derivative induced B cell proliferation in lymphocytes from males, which was in contrast to lymphocytes from females where a statistically significant suppression was found. A similar hCG-induced suppressive effect was found before menarche, after the menopause and in two patients with Turner's syndrome, suggesting that a gene(s) on the Y chromosome exerts a regulatory function and thus prevents the hormone from inducing suppressor T cells.

Aging↗
PubMed1981

In vitro induction of human suppressor T cells by a chorionic gonadotropin preparation.

Human chorionic gonadotropin (hCG) in physiological retroplacental concentration has been shown to possess the capacity of inducing human lymphocytes which are subsequently competent to depress an antibody response induced by purified protein derivative of tuberculin, phytohemagglutinin, lipopolysaccharide and pokeweed mitogen. These suppressor cells inhibited the T cell-dependent mitogen-induced activation of lymphocytes synthesizing IgM, IgG and IgA. No suppression by hCG-induced cells was observed in Epstein-Barr virus activated cell cultures, indicating a T cell origin of the target cell. It is suggested that this may represent a mechanism for the cellular basis of an hCG-induced immunosuppressive effect in pregnancy.

Adult↗
PubMed1980

In vitro induction of murine suppressor T-cells by human chorionic gonadotropin.

Human chorionic gonadotropin (HCG) has previously been considered to be immunosuppressive and, thus, by prohibiting maternal rejection of the fetal transplant, to be one of the factors responsible for the successful outcome of pregnancy. The mechanism by which HCG exerts its pregnancy retaining effect is, however, as yet unknown. The present study shows that HCG has the capacity in mice of inducing lymphocytes which are subsequently competent to depress a polyclonal antibody response induced by different B cell mitogens. It is therefore suggested that HCG may exert its feto-protective action by inducing suppressor T cells. These lymphocytes would thus prevent the activation of cells which are responsible for transplant rejection.

Animals↗
PubMed1980

[Surgery of carpal tunnel syndrome without interfascicular neurolysis].

198 operations of carpal tunnel syndrome demonstrated that the simple dissection of the ligamentum carpi transversum is followed by excellent results. One year after the operation among the hands with thenar muscle atrophy 82% returned to normal and 11% were improved. Among the cases with preoperative complete loss of function (axonotmesis) of the power grade 5 postoperatively. The capacity for regeneration is not different between the motor and the sensory fibers of the nerve. The restoration of the muscle power depends on the grade of the muscle fibrosis after long denervation. The comparison with the results of other authors demonstrates no advantage of the additional interfascicular neurolysis.

Carpal Tunnel Syndrome↗
PubMed1979

The immunodepressive effect of human glucoproteins and their possible role in the nonrejection process during pregnancy.

Human chorionic gonadotrophin (HCG) and human chorionic somatomammotrophin (HCS) were shown to suppress the proliferative T and B cell response induced by different mitogens in human and mouse lymphocytes. Thyroid stimulating hormone (TSH), sharing the alpha-chain subunit with HCG was devoid of effect suggesting that the immunosuppressive entity is localized within the beta-chain subunit. Human growth hormone (HGH) which is partly biologically cross-reactive with HCS did not impair mitogen responsiveness. HCG was also able to inhibit the differentiation of cells since the induction of antibody-formation was depressed. Expression of plaque forming cells was also reduced by addition of HCG directly in the PFC assay possibly reflecting the anti-complementary effect of this hormone, since cell mediated lysis of target cells by Con A activated lymphocytes, which is not complement-dependent, was unaffected by adding HCG in the assay system.

Animals↗