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Biomedical subjects

T G Brien

Publications and source records attributed to T G Brien.

5 recordsLinked to original sources
PubMed1976

Longitudinal study of the free cortisol index in pregnancy.

Total plasma cortisol, the 'cortisol resin uptake ratio' (cortisol RUR), and 'free cortisol index' (FCI) were estimated in 23 pregnant women from 12 weeks to term and at six weeks post partum. Total plasma cortisol rose continually throughout pregnancy; the cortisol RUR rose up to 20 to 23 weeks and then fell slowly and the FCI also rose although more slowly than the total cortisol. All parameters fell to non-pregnant levels at six weeks post partum. It is confirmed that a true rise in metabolically active cortisol occurs during pregnancy.

Female↗
PubMed1976

The adrenocortical status of patients with thyroid disease.

Plasma cortisol, cortisol resin uptake ratio and free cortisol index was measured in twenty-seven euthyroid, ten hypothyroid and fifteen hyperthyroid subjects. No difference was observed between euthyroid subjects and patients with thyroid disease for any of the three parameters tested. The significance of these findings is discussed in the light of earlier reports linking thyroid activity with the levels of corticosteroid binding globulin.

Humans↗
PubMed1975

Cortisol metabolism after oral contraceptives: total plasma cortisol and the free cortisol index.

Plasma concentrations of cortisol, cortisol resin uptake ratio (cortisol RUR) and free cortisol index (FCI) were measured in women taking combined oestrogen/progestogen and progestogen only oral contraceptives. Compared to control subjects, women taking the combined pill had elevated cortisol and cortisol RUR values in both the morning and afternoon but there was no significant change in FCI. Women taking the progestogen only pill had essentially normal levels of cortisol, cortisol RUR and FCI at both times of the day. As far as could be judged, diurnal variation of total cortisol and FCI remained unimpaired in women taking both types of pill. The FCI measurements indicated that there was no significant increase in metabolically active cortisol in women taking either the combined oestrogen/progestogen or the progestogen only type of oral contraceptive.

Contraceptives, Oral↗