Biomedical subjects
Publications and source records attributed to T G Novikova.
Blood microcirculation and immunity were studied in 52 patients with rheumatic valve disease associated with pulmonary hypertension. The most pronounced changes were observed in patients with "active" pulmonary hypertension. Microcirculatory and immune disorders are likely to be pathogenetical factors aggravating prognosis of pulmonary hypertension.
Deterioration of the condition in patients with arterial hypertension was found during the critical days of individual biorhythms and correlated with changes in the vascular and intravascular sector of the microcirculation. The peculiarities of individual biorhythms and state of microcirculation in patients with arterial hypertension allow to carry out timely and adequate drug correction of microcirculation disorders and central hemodynamics.
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The existence of testosterone-binding globulin (TBC) homogeneous by the association constant (of the 10(8) M-1 order) and sedimentation characteristics (sedimentation coefficient--4S) was demonstrated in various groups of rabbits (mature males and females, pregnant females and fetuses, immature males). The level of the TBG binding capacity failed to show any marked differences in all the ontogenetic groups. The TBG level was rather close in the rabbit mother and fetus. Estradiol, estron, progesterone, cortizol possessed no affinity to this protein. Dehydrotestosterone affinity was about three times greater than that of testosterone. When TBG was used in the competitive protein-binding analysis of testosterone and other protein-bound androgens in the blood plasma of men, women and rabbits (male and female) there were obtained results coinciding with those of other authors. This permitted to recommend TBG for wide practical use in the competitive protein-binding analysis.