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Biomedical subjects

T G Sarycheva

Publications and source records attributed to T G Sarycheva.

17 recordsLinked to original sources
PubMed1998

[Hematological investigations in conditions of long-term space flights].

In the nearly 15-month mission aboard MIR the cosmonaut-physician and members of three crews (MIR-15, -16, and -17) carried out a program of hematological investigations. Most of the changes related to the red blood system and included reduction in hemoglobin and hematocrit. Erythrocytes had decreased concentration and took on abnormal forms. There were also signs of altered metabolism of erythrocytes. Of interest are phase-by-phase variations in the levels of erythrocytes in the course of long-term stay in microgravity, and absence of a convincing correlation between hemoglobin, erythrocyte and hematocrit levels. But for lymphocytosis that returned to the norm already on the first day of recovery, no material changes occurred to the leukocyte profile. Investigations at the landing site displayed erythropenia, decreased reticulocytes and ensuing reticulocyte reaction, and gradual regain of the erythrocyte number that can be viewed as a normal physiological reaction of the blood system to the set of factors of spaceflight and early readaptation. Besides, the investigations showed a large individually of blood reactions to prolonged stay in space flight.

Adaptation, Physiological↗
PubMed1997

[Dynamics of the hematological shifts in females during antiorthostatic hypokinesia].

The purpose of the present study was to perform comprehensive hematological investigations of females in a 120-day head-down (-5 degrees) bed rest and in the period of recovery. Morphometric, cytochemical parameters of erythrocytes and lymphocytes, erythropoietic activity and turnover of iron were analyzed in 8 female subjects assigned into two groups of 4. In group A, countermeasures were applied throughout the experiment; in group B, they were used only in the recovery period. Shifts observed in a number of parameters of the turnover of iron and morphometry of the blood cells are most likely adaptive by nature and demonstrate the reaction of blood to the hypokinesia and recovery factors.

Adult↗
PubMed1997

[Experience in the use of flow scintillator Cobas Micros-18 OT in hematological practice].

Clinical analysis of the blood is a most prevalent investigation in practical medicine. The need in effective assessment of the results of blood analysis prompted the creation of automated flow systems. Our task was to analyze the blood of normal subjects and patients by Hoffmann La Roche Cobas Micros-18 OT (France). It is a completely automated hematological analyzer used for in vitro diagnostic tests of whole blood. The work consisted of two steps: 1) comparison of the results of leukocyte and red cell counting by Cobas Micros and Goryayev chamber and 2) assessment of the leukocyte formula in blood donors and patients with diseases other than hematological by the Cobas Micros device and compare the results with the data of visual assessment in optic microscope. The results of analysis by the automated scintillator, Goryayev's chamber, and optic microscopy were compatible. Cobas Micros is very convenient for analysis of liquid blood on an outpatient and inpatient basis and during overall screenings. The device facilitates the deciphering of the leukocytic formula and assessment of the status of formed elements of the blood in mass screenings and detection of abnormalities.

Erythrocyte Count↗
PubMed1997

[Principles of creating software and equipment for automating the workplace of laboratory physician].

Automation of laboratory tests is a pressing problem of today, for examinations of the hemopoietic system is a priority in the diagnosis of the majority of diseases and in detecting the effects of unfavorable ecological factors on man; in addition, laboratory studies are time- and labor-consuming. A system "Automated Work Place of a Laboratory Physician" has been developed, which permits automated scanning of a routinely stained blood smear with automated focussing on the detected objects. A preset number of objects is filed in the archive for further identification by a morphologist. The results can be stored in the information database for each patient and be transferred through telecommunication network. The system includes a computer hypertext Blood Atlas.

Automation↗
PubMed1993

[The immunological phenotype and proliferative activity of the tumor lymphocytes in multiple myeloma].

An immunological phenotype of blood lymphocytes and proliferative activity of tumor cells were studied using a panel of monoclonal antibodies to lymphocyte differential antigens and tracer 3H-thymidine, respectively, in 84 patients with multiple myeloma. CD-19 and CD38 antigens were identified as markers for circulating tumor lymphocytes. The count of CD38+ and CD71+lymphocytes correlated with the count of marrow plasmocytes including 3H-thymidine in the disease recurrence. Proliferative parameters of blood lymphocytes, plasmocytes and lymphocytes of the bone marrow were identical being, consequently, elements of the same tumor clone.

Adult↗
PubMed1993

[The morphofunctional characteristics of the bone marrow erythroid cells in some forms of the myelodysplastic syndrome].

Refractory anemia (RA) and RA with blast excess (RABE) showed inhibited proliferation of bone marrow erythroid cells (EC), the lowest values being in RABE. The latter, however, was accompanied with the highest count of PAS-positive EC, uneffective erythropoiesis being present in both RA and RABE. In sideroblast anemia the above proliferation was also inhibited, but uneffective erythropoiesis played much more pronounced role in pathogenesis of this anemia than in RA and RABE. The percentage of PAS-positive EC averaged 39.0%. The findings contribute to more profound understanding of anemia arising in myelodysplasia syndrome, to more accurate evaluation of therapeutic effect and prognosis in the above disease.

Aged↗
PubMed1993

[Anemic syndrome in chronic hepatitis and liver cirrhosis].

Regularities in the development of anemia in patients with chronic hepatitis or hepato-cirrhosis were studied with regard to the pattern and stage of the affection of the liver. The impact of inefficient erythropoiesis on anemia development in patients with chronic diffuse diseases of the liver was demonstrated. Reasons of the red cells imperfection that caused their rapid hemolysis were indicated. In the bone marrow of chronically ill patients there were lower levels of early precursors of erythropoiesis with their proliferative activity reduced. On the basis of the data obtained the authors gave practical recommendations for anemia treatment.

Adult↗
PubMed1990

[The determination of erythrocyte deformability using a filtration method].

Red cell deformability was assessed in donors, patients with chronic renal insufficiency, and with thermal injuries by filtration through special filters. Filtration of donor red cells decreased their count but insignificantly; in patients with chronic renal insufficiency this characteristic was lowered, particularly so before hemoperfusion, whereas after hemoperfusion red cell deformability improved. Changes of red cell deformability in patients with thermal injuries is an objective criterion reflecting the status of the erythron peripheral component in connection with the severity of injury and course of its healing.

Burns↗
PubMed1987

[Differential diagnosis of unconjugated hyperbilirubinemia].

Eighty-four patients with unconjugated hyperbilirubinemia were examined for erythron. The authors managed to reveal a group of patients with evident signs of the derangement of the nucleus-containing cells of erythropoiesis which was manifested in the accumulation of SIA-positive material in the cytoplasm and by the presence of morphological abnormalities in the peripheral red blood cells.

Adolescent↗
PubMed1987

[Erythron in patients with polycythemia vera during treatment by erythrocytapheresis and bloodletting].

An analysis of the results of determination of erythropoietin in the blood plasma of patients with polycythemia vera and data on the kinetics of erythroid cell proliferation led to a conclusion that erythrocytapheresis more than bloodletting stimulated the production of erythropoietin and the cell proliferative potential. Activation of regenerative processes probably determined by deinhibition of the normal clone of bone marrow erythroid cells, can account for the mechanism of a therapeutic effect of erythrocytapheresis in patients with polycythemia vera.

Blood Component Removal↗
PubMedDate not supplied

[Anemia in patients with chronic kidney failure undergoing systematic hemodialysis treatment].

A study of 24 patients with chronic renal failure and varying degrees of uremia and clinical symptoms was carried out in order to assess the mechanisms of anemia developing in patients on systematic hemodialysis for chronic renal failure. Blood clinical and biochemical parameters were evaluated. Sternal bone marrow puncture was performed to assess erythron status. Proliferative activity of bone marrow erythroid cells was assessed by autoradiography. Ineffective erythropoiesis was studied using MacManus' PAS test. The results of the study suggest that proliferative activity of bone-marrow erythroid cells is reduced while ineffective erythropoiesis is increased in patients with terminal chronic renal failure, treated by systematic hemodialysis, and largely explain the mechanism of anemia in these patients.

Adolescent↗