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Biomedical subjects

T Górowski

Publications and source records attributed to T Górowski.

At least 19 recordsLinked to original sources
PubMed1992

[Results of 3-stage treatment: (I) corticotherapy, (II) linear acceleration and (III) orbital decompression in 206 patients with malignant Graves ophthalmopathy].

There is no, so far, a rational method of therapy based upon the etiology of autoimmune Graves' ophthalmopathy. As a malignant Graves' ophthalmopathy we defined the most severe eye changes leading to the sight loss or permanent disability of vision which are classified as exceeded class 3c according to the eye changes classification of the American Thyroid Association [27]. The aim of the study was to develop the most efficacious method of therapy for malignant Graves' ophthalmopathy. The material consisted of 206 patients treated according to the 3-stage method: 1-st--corticotherapy, 2-nd--radiotherapy, including linear accelerator, 3-rd--orbital decompression. Moreover, in four patients plasmapheresis was applied and in additional five cyclosporine was administered. In all 206 patients the estimation of the results of the treatment was based on the Donaldson ophthalmopathy index [4]. It has been proved that corticotherapy combined with linear accelerator radiotherapy has been the most efficacious method of treatment. It has also the least number of side effects. Orbital decompression as the 3-rd stage of treatment was employed in those cases in which the previous two stages of medical therapy were unsuccessful.

Adrenal Cortex Hormones↗
PubMed1992

[Anaplastic thyroid carcinoma developed after treatment of "hot" thyroid nodule with radioiodine].

A case of 55 years old woman with "hot" right lobe toxic thyroid nodule, presenting with paroxysmal atrial fibrillation, and therefore treated with 131I 666MBq (18 mCi) is described. After six years she became pyrexic and suffered of severe cough proxyisms. The fine needle biopsy of the above nodule showed the presence of anaplastic thyroid carcinoma. Strumectomy followed by local radiotherapy resulted in complete disappearence of all symptoms. The microscopic of the removed thyroid tissue confirmed the above diagnosis. After 22 months' observation the patient remained in good general condition. The possible reasons for the development of the thyroid carcinoma in this case are discussed.

Carcinoma↗
PubMed1990

[Ocular hypertension in patients with infiltrative-edematous exophthalmos in Graves' disease].

The increase of the IOP--5 to 30 mm Hg--was observed in patients in whom severe infiltrative changes in the motor muscles dominated the clinical picture. Characteristic for glaucoma changes of the visual field and optic papilla were not seen, the angle was open and the outflow coefficient was in normal limits. The normalization of the IOP was obtained after decompensation of the orbits when the exophthalmos and the infiltrative changes in the motor muscles of the eye receded.

Combined Modality Therapy↗
PubMed1979

Airborne radioiodine contamination caused by 131I treatment.

Estimation of exposure from 131I inhaled from unsealed sources during laboratory procedures and from that exhaled by patients treated with 131I has revealed that the permissible levels have been exceeded by a factor of 2-5, although the absorbed activity was found to be between 1 and 10% of the maximum permissible absorption of 131I inhaled through the lungs. The fall in 131I concentration in the air exhaled by 19 hyperthyroid patients, to whom 131I was administered in a dose of several hundred MBq, could be expressed by a two-component equation, which reflects the changes in 131I concentration in the blood.

Air Pollutants↗
PubMed1978

Thyroid function in early sub-acute thyroiditis.

A 53-year-old woman with an early form of de Quervain's disease involving both thyroid lobes was found to have her thyroid uptake of iodine suppressed, although the serum thyroid hormone concentrations were normal while the administration of TRH resulted in significant increase in the serum TSH concentrations. After administration of TSH the thyroid reserve was found to below. The diagnosis of sub-acute thyroiditis was confirmed on biopsy. The above data seem to indicate that the suppression of the thyroid uptake in the early stage of de Quervain's disease may be directly caused by the inflammatory condition of the gland, rather than, as is usually the case, by the excess of thyroid hormones and, consequently, by the suppression of pituitary TSH secretion.

Female↗
PubMed1976

Some comparative studies using 99mTc and 131I in thyroid scanning.

By comparing thyroid scans made with 99mTc and 131I in 40 euthyroid goiter patients large discrepancies were found in 20% of all cases. For example, "warm" nodules on 99mTc scans were found to be "cold" on 131I scans, or a "cold" nodule on a 99mTc scan was observed as a "warm" one on a 131I scan. The above discrepancies seem to result from the differences in the metabolism of the two radioisotopes in the thyroid and those in the time which elapsed between the administration of the radioisotope and the execution of the scan. Generally speaking 99mTc thyroid scintigraphy should not be recommended as a routine technique in adults, its usefulness being limited to the cases in which 131I scans were found to be illegible. "Cold" nodules on 99mTc scans should also be reexamined after T3 stimulation.

Adult↗