Biomedical subjects

T Górski

Publications and source records attributed to T Górski.

At least 19 recordsLinked to original sources

PubMed2004

The use of vinca alkaloids in adult patients with refractory chronic idiopathic thrombocytopenia.

The aim of the study was to evaluate the application of vincristin or vinblastin in patients with chronic idiopathic thrombocytopenic purpura (ITP), resistant to corticosteroids or with partial contraindication to their application. Twenty-two patients were treated with vincristin or vinblastin in doses of 2 and 10 mg, respectively. Eight of these patients were additionally administered prednisone in an oral dose of 0.5 mg/kg body mass (bm). Two-hour intravenous infusions of drugs were made once a week, at least three times. In every patient, the platelet count was evaluated before and after the three infusions. A rise of the platelet count of at least 100 x 10(9)/l was assumed to signify improvement. Statistically significant improvement (P <0.01) was obtained in nine (41%) patients (including five (35%) patients treated with vinca alkaloids only and in four (50%) patients treated with vincristin and corticosteroids). On the average, 8 weeks after the termination of the treatment there was a 40% drop in the platelet. Patients with a shorter duration of the disease and without detectable platelet antibodies responded well to the treatment more frequently. Minor complications were observed in five patients (23%), notably in the form of paresthesia. Leukopenia was not present. Vinca alkaloids could find their application in clinical situations requiring short-term increase of the platelet count in chronically ill patients with ITP, resistant to corticosteroids or with counterindication to their application.

Adrenal Cortex Hormones↗

PubMed2003

Hemoglobin F in primary myelofibrosis and in myelodysplasia.

Our study investigated two groups of adult patients with established diagnoses of primary myelofibrosis (21 patients) and myelodysplastic syndromes (MDS) (21 patients). The objective was to assess fetal hemoglobin (HbF) concentration and to investigate correlations with organomegaly and extramedullary hematopoiesis and with the level of anemia and blood transfusion requirement. In all patients, the diagnosis was confirmed by histopathological examination. Patients with myelofibrosis were investigated by ferrokinetics using 59Fe. The percentage of marrow sideroblasts was assessed in patients with refractory anemia with ringed sideroblasts. Increased values of HbF were found to occur both in patients with myelofibrosis and with MDS, although a higher incidence and higher concentrations were evident in patients with myelofibrosis. Statistically significant increases in HbF concentration were found when there was accompanying organomegaly, as compared to patients without this feature. The average HbF concentration in both groups of patients under study was twice as high in cases with as in those without marrow fibrosis. The difference was statistically significant. Increased HbF levels appear to correlate with extramedullary hematopoiesis. HbF concentration did not correlate with the level of anemia or with requirement for blood transfusion.

Adult↗

PubMed1998

[Vibration syndrome and occupational exposure in Poland].

The objective of the study was to analyse the data on the exposure to vibration, and the incidence of vibration syndrome in individual branches of the national economy and voivodships. The data were obtained from the records of The Nofer Institute of Occupational Medicine in Lódź, containing reports submitted to the Institute every three years, and the literature on fragmentary analyses of this kind of exposure. Although, the number of persons exposed to vibration, and the incidence of occupational diseases induced by vibration have decreased, the material collected provide evidence that vibration syndrome still plays an essential role in occupational pathology. The decrease in the vibration syndrome incidence observed during the years 1982-97 was lower than the decline in the number of persons exposed to vibration, but the ratio of the number of cases to the number of those exposed remained unchanged (2.1). In 1994-97, forestry workers constituted the largest working population exposed to vibration, and the number of persons with diagnosed vibration syndrome significantly increased, however, exposure to vibration in this branch of economy considerably declined. In the mining industry, a significant decrease in the number of persons exposed to vibration, as well as in the incidence of vibration syndrome was observed at that time. The worse situation in forestry might result from the past negligence of hygiene norms or less effective diagnosis in early stages of the disease development. The lack of measuring and monitoring of vibration intensity in the working environment is an alarming observation in view of the fact that both the number of persons exposed, and the incidence of occupational diseases caused by this kind of exposure are still high.

Adult↗

PubMed1993

The influence of cigarette smoking on sister chromatid exchange frequencies in peripheral lymphocytes among nurses handling cytostatic drugs.

Genotoxic compounds and various cancer chemotherapeutic agents can interact with tobacco smoke synergistically, especially among cigarette smoking nurses handling cytostatic drugs. The aim of the study was to examine the hypothesis that tobacco smoking has a greater influence on sister chromatid exchange (SCE) frequencies among nurses than the influence of cytostatics in working conditions. The frequencies of SCE in lymphocytes investigated among hospital staff who handle anti-cancer drugs were higher than in a control group which did not handle them (smokers and non-smokers). The increase of SCE frequencies was observed more often among cigarette smoking nurses and less among non-smoking nurses who handle cytostatics 3 times a week.

Antineoplastic Agents↗

PubMed1991

The effect of organic chlorine compounds and their metabolites present in human milk on newborn mice.

The effect of pesticides and their metabolites (DDE, DDT, DDD, alpha, beta and gamma-HCH and PCBs) isolated from human milk on the blood and liver morphology of the mouse were studied. Mouse neonates were fed an extract of the organochlorine compounds in linseed oil for a period of 6 weeks. The lowest dose used in the experiment equalled that which a human infant can receive with its mother's milk, calculated per gram of body weight. Doses 10 and 100 times higher were also used. At the end of the experiment, tissue samples for electron microscopy and blood samples for haemotological examination were taken. Haematological examinations, in mice receiving pesticides, revealed a significant rise in the number of Heinz bodies in erythrocytes and an increased number of lymphocytes. These changes were related to the concentrations of the organic chlorine compounds that the animals were given. Electronmicroscopy demonstrated that organochlorine pesticides at doses equal to that might be received by infants caused proliferation of the smooth endoplasmic reticulum in hepatocytes without any clear damage to other subcellular structures. Doses 10 and 100 times higher resulted in more extensive proliferation of the smooth endoplasmic reticulum, reduction of the rough elements of the endoplasmic reticulum and damage to mitochondria. The latest changes were associated with an increased number of prominent Kupffer cells and the appearance of immigratory cells with traits characteristic of lymphocytes and monocytes.

Administration, Oral↗

PubMed1991