[Deep injuries of the articular cartilage].
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Biomedical subjects
Publications and source records attributed to T Gaździk.
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The localization, intensity, and character of the enzymatic reactions of the following enzymes responsible for the oxygenic and nonoxygenic respiration were under examination: succinic dehydrogenase (SDH), NADH tetrazole reductase (NADH-R), and lactate dehydrogenase (LDH). The features of the enzymatic reactions enumerated above were tested in male gonads of the rats on their 1st, 4th, 7th, 15th, 30th, 45th, 60th, 90th d and 1.5 year of post-fetal life. It was estimated on the examined reactions that their metabolic maturity in the gonad was reached on the 45th d of the rat's life.
The described experiments showed the influence of a single dose of cadmium chloride (1.5 mg CdCl2/kg body mass) applied intraperitoneally on the activity of succinic dehydrogenase (SDH), NADH tetrazole reductase (NADH-R), and lactate dehydrogenase (LDH) in the rat's male gonad. It was ascertained that disturbances of the reaction begin to occur in the 7th d of post-fetal life: they increase gradually, first at the circumference and then the centre of the organ reaching their maximum in 1.5 year old rats.
Effects of N-ethyl-N-nitrosourea (ENU) on cytochrome P-450-dependent monooxygenase system activity and the ultrastructure of the liver cells are examined. Significant changes in the structure of mitochondria, smooth and rough endoplasmic reticulum and Golgi apparatus are observed, particularly in 3rd zone of acinus. Cytochrome P-450 and monooxygenase activity shows decrease, but cytochrome b5 and NADH-cytochrome b5 reductase activity increases.
The morphometrical data of the rat testis were studied between the 1st day and 1.5 year of life under physiological conditions and after intraperitoneal injection of a single dose of cadmium chloride (1.5 mg CdCl2/kg body weight). Under physiological conditions three main period of development occur: between the 1st and 30th day of life, between the 30th and 45th day of life, and after the 45th day of life. The greatest changes after the injection of cadmium were noticed in the period between the 15th and 30th day of life. The periphery of the organ was the first to suffer severe damage.
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The paper describes morphological and cytochemical changes in rat testis starting with the first day of postnatal life to 1,5 year under physiological conditions and after single intraperitoneal injection of 1,5 mg CdCl2/kg. We have proved that sensitive cells in testis are: spermatogonia B and primary spermatocyte. Maximum morphological and cytochemical changes occur in the testis of 30-60 days old rats and in 15 year old rats following destruction of the testis begins in capillar walls and blod-testis barrier.