Biomedical subjects
Publications and source records attributed to T Georgescu.
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Antiproliferative and antiviral activities of a type alpha human leukocytic interferon on several heteroploidic cell lines: HeLa, HEp-2, and T-10, a cell line of malignant origin (glioblastoma) were investigated, as compared to subcultures of human embryo fibroblasts. The tumor cell multiplication rate decreased proportionally to the amount of interferon in the culture medium. The highest interferon concentration used in our experiments (1,000 mu/ml) induced a decrease of the normal cell multiplication rate (human embryo fibroblasts). The same amount of interferon had a cytotoxic effect against the T-10 cells, but this phenomenon is reversible if the interferon is excluded after 24 h from the culture medium. There was no quantitative relation between the magnitude of the antiviral and of the cytotoxic effects of the type alpha human interferon on the tested cellular substrates.
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The authors investigated the late results, or survival at 5 years after the intervention, in 170 patients operated for breast cancer. The total number of survivors at 5 years was of 71 patients, of which 78 belonged to stages I and II, and only 3 to stage III. The authors present their personal attitude for such cases, and stress some of the difficulties encountered in the application of complex therapy. Of the late complications noted, which totalled 58 cases, the authors mention generalized carcinomatosis in 17 patients, pleuro-pulmonary metastases in 14 patients and 11 cases of chronic oedema of the arm, or the so-called "thick arm after Halstead operation".
Seven patients with tumor-like granulomatous lesions of the peritoneal cavity were cured, except one, by correct surgical intervention removing the inflammatory hyperplastic tissues and restoring the permeability of the alimentary tract. The exact diagnosis was suggested by the existence in the personal history of the patients of one or several interventions on the peritoneal cavity (6 of 7), and was confirmed by intraoperative, sometimes repeated, microscopic examination, rendering evident a fibrogenous giant cell granulomatous process; the presence of foreign bodies, especially suture threads or crystals (the latter characterized in polarized light) is very helpful for the diagnosis of these tumor-like inflammations.
The authors present false pancreatic cysts and fistulae that have been encountered inthe practice of the I-st Clinic of Surgery from Tg-Mureş over a period of 10 years (between 1964 ans 1979). The author's personal cases are presented and the rarity of this type of disturbances is stressed. A total of 14 cases are described, of which 8 were false pancreatic cysts and 6 were false pancreatic fistulae. The major complications that occurred in the cases with false pancreatic cysts the most severe was the intra-cyst haemorrhage, that was encountered in 2 patients (of which one developed severe shock), and peritonitis, following rupture of the cyst in the peritoneal cavity. The 6 pancreatic fistulae have developed following surgery (3 cases), trauma (one case), and acute pancreatitis (2 cases). The treatment of the false cysts consisted in the external drainage (two emergencies), and cyst-gastrectomy. Pancreatic fistulae have benefited from fistulo-gastrostomy (two cases), while the remaining 4 patients were treated conservatively. Only one death was recorded in this group of patients.
Histological, histochemical and electronmicroscopic investigations were carried out on gum biopsies taken from cases with chronic marginal periodontal disease before and after the treatment with staphylococcic vaccine, thus, morphopathologically proving the findings of Gafar et al. (1985) and of Georgescu et al. (1973; 1974; 1975; 1979; 1995). Before treatment, gum lesions were severe, consisting in an abundance of polymorphic inflammatory infiltrates in the chorion along with oedema and disorganised connective fibres, atrophies and ulceration of the mucosa, purulent deposits at the surface with bacteria and fungi. After the treatment with the staphylococcic vaccine, an epithelial regeneration was seen together with the absence of the chronic inflammation. The intensely fibroparius granulated tissue was also noted, in all cases observing abundant connective fibres, accounting for good results after treatment, notably the firmness of the tooth fitting.