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Biomedical subjects

T Goggin

Publications and source records attributed to T Goggin.

23 records · Page 2Linked to original sources
PubMed1985

A prospective study between carbamazepine, phenytoin and sodium valproate as monotherapy in previously untreated and recently diagnosed patients with epilepsy.

One hundred and eighty one patients with previously untreated epilepsy were randomised to sodium valproate, phenytoin or carbamazepine as monotherapy and followed up for a median period which ranged from 14 to 24 months. All three drugs were highly effective in the control of generalised seizures but less effective for partial seizures. Excellent or good control was achieved with therapeutic levels of sodium valproate and carbamazepine, but with subtherapeutic levels of phenytoin.

Adolescent↗
PubMedDate not supplied

Hypothalamic pituitary function testing on children receiving carbamazepine or sodium valproate.

An investigation of hypothalamic pituitary axis (HPA) function was performed on children and adolescents receiving long-term monotherapy with either carbamazepine (CBZ) or sodium valproate (NaV). There was a significant reduction in total T4 in the CBZ group. Free T4, T3, and thyroid-stimulating hormone response to thyrotropin-releasing hormone were similar in both groups. All patients produced an adequate growth hormone response to either arginine or L-Dopa. Basal cortisol levels were similar in both groups. An appropriately increased response in luteinising hormone, prolactin, testosterone, and oestradiol occurred in those after puberty. The results suggest that HPA function in children is not compromised by long-term monotherapy with CBZ or NaV.

Adolescent↗
PubMedDate not supplied

Serum bilirubin levels with antiepileptic drugs.

The incidence of reduced bilirubin levels in 168 outpatients with epilepsy, compared with levels in 69 controls, has been investigated. Highly significant (p less than 0.001) reductions in average bilirubin levels were noted for carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PB), and multiple drug groups. A marginally significant (p less than 0.05) reduction in bilirubin levels occurred in patients treated with valproate (VPA) which, unlike the other drugs, has not been shown to induce hepatic enzymes.

Adult↗