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T Gräser

Publications and source records attributed to T Gräser.

38 records · Page 3Linked to original sources
PubMedDate not supplied

Heterogeneity of the response of venous smooth muscle to arterial endothelium-derived relaxing factor (EDRF) in respect of the role of nitric oxide.

In bioassay and organ bath experiments, the responses of different canine venous preparations to arterial and their own EDRF were studied. Vena jugularis, vena femoralis and vena mesenterica relaxed on both EDRFs released by acetylcholine. Vena saphena, venae cordis and vena portae did not show endothelium-dependent dilation, either under bioassay or in organ bath experiments. All the veins tested relaxed completely after sodium nitroprusside administration. The identity of EDRF and nitric oxide is not confirmed by this study.

Animals↗
PubMedDate not supplied

Effects of lysophosphatidylcholine and palmitylcarnitine--lipid metabolites produced in ischemia--on porcine coronary and rabbit femoral arteries.

In organ bath experiments, amphiphilic lipids lysophosphatidylcholine (LPC) and palmitylcarnitine (PLC) produced a small increase in tension of nonprecontracted strips of porcine coronary artery with a subsequent decrease to initial level after high concentrations of the agents, both in intact and endothelium-denuded preparations. Both amphiphiles produced dose-dependent but incomplete relaxation of intact coronary strips precontracted with high potassium. The effect of PLC was more pronounced. LPC, 3.10(-6) mol.l-1, did not influence Ca++-dose-response relationships, while PLC in concentration of 10(-5) mol.l-1 abolished the decline in the second Ca++-dose-response curve. Neither PLC nor LPC in concentrations of 3.10(-6) mol.l-1 influenced endothelium-dependent relaxation produced by bradykinin precontracted with high potassium porcine coronary artery. Both amphiphiles did not change tension of nonprecontracted and precontracted with phenylephrine, 10(-6) mol.l-1, rabbit femoral artery ring segments or Ca++-dose-response relationships with and without endothelium.

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