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Biomedical subjects

T Graham

Publications and source records attributed to T Graham.

At least 109 records · Page 6Linked to original sources
PubMed1980

Histopathologic evaluation of livers of pregnant hamsters infected with Leptospira canicola.

Pregnant hamsters were inoculated with Leptospira canicola by an intraperitoneal route. Grossly, the livers were enlarged and pale yellow. On light microscopic examination, disruption of the hepatic cords, as well as granulation of hepatocyte cytoplasm, was evident. On electron microscopic examination, the livers had evidence of severe cellular degradation as early as post-inoculation hour (PIH) 24. At PIH 96, pathologic changes were more pronounced. The rough endoplasmic reticulum was swollen and there was membrane disruption. These changes were not observed in the livers of control animals. In addition, livers of the fetuses at PIH 72 exhibited severe degenerative changes.

Animals↗
PubMed1980

Muscle metabolites, force, and perceived exertion bicycling at varying pedal rates.

Muscle metabolites, force, and perceived exertion bicycling at varying pedal rates. Med. Sci. Sports Exercise, Vol 12, No. 5, pp. 345-351, 1980. The relative significance of central (VE, Vo2, heart rate) or peripheral (muscle tension, muscle metabolites) factors on perceived exertion (RPE) was investigated with bicycle exercise by varying pedal rate while maintaining a constant power output. Six healthy male subjects exercised at zero load, submaximal (70% Vo2max) and maximal exercise intensities with pedal rates of 40, 60, 80, and 100 rpm. With changing pedal rate and constant power output, there were numerous examples of significant changes in the central factors with no change in RPE and vice versa. Similarly, measures of muscle and blood lactate, NAD, glycogen, ATP, and CP failed to demonstrate any local metabolic factor that correlated with RPE. Force exerted on the pedals and the rate of force generation approximated RPE changes, but the detailed correlation analysis was nonsignificant. None of the central or peripheral factors alone are related to RPE. Thus, RPE must be derived from a number of peripheral and/or central factors in a complex manner.

Adult↗
PubMed1978

Peritoneoscopy in the management of breast cancer.

Peritoneoscopy has been recommended by the Combined Breast Clinic at the Provincial Hospital, Port Elizabeth, since 1975, mainly to confirm or exclude metastatic involvement of the liver. Experience with 27 procedures is reviewed. Peritoneoscopy is shown to be a useful aid in the staging and management of selected cases of breast cancer. Positive findings, confirmed by histological examination, were recorded for 5 patients. Negative findings in 22 patients were equally helpful, and were found to be reliable, in that none of these patients had evidence of liver involvement during the follow-up period, while in 5 patients there was evidence of metastases elsewhere.

Breast Neoplasms↗
PubMed1978

NAD in muscle of man at rest and during exercise.

NAD can be used to assess the adequacy of oxygen availability to the respiratory chain. An enzymatic assay was established for NAD in human muscle biopsy samples. It gave reliable, reproducible results. The variation within and between subjects was less than 12%. Muscle NAD and lactate were determined at rest, and after bicycle ergometry work requiring approximately 75 and approximately 100% VO2 max (six subjects, four tests each). A positive (P less than 0.01) linear relationship between resting muscle NAD and percent slow twitch fibers was found, suggesting that fiber types may have different NAD content. Muscle NAD decreased during submaximal and maximal work (P less than 0.05). A large portion (73%) of the NAD reduction could be accounted for by increased muscle water. No relationship could be established between NAD and lactate. The negative linear relationship (P less than 0.01) between the muscle/blood ratio and percent slow twitch fibers is another indication of the fiber having different metabolic responses to the activity.

Adult↗
PubMed1977

Effects of hyperoxia on leg blood flow and metabolism during exercise.

These experiments were designed to investigate the effects of O2 breathing on limb blood flow and metabolism during exercise. Six subjects took part in the study. Four subjects breathed air or 100% O2 while pedaling a Krogh bicycle at 150 W (55-70% of maximal aerobic capacity). Two subjects breathed either 60% or 100% O2 while working at a power output at or slightly in excess of their maximal aerobic capacities. The major findings of the study were 1) leg blood flow is reduced during exercise when comparing hyperoxia with normoxia; 2) VO2 of the exercising limb is not different during hyperoxia; 3) O2 delivery to the leg (the product of blood flow and arteriovenous O2 difference) is not significantly different in the two conditions; and 4) blood pressure is not markedly affected in the experiments at 150 W. Since BP was not different during hyperoxia, at a time when flow was reduced by 11%, this suggests an increased resistance to flow in the exercising limb. In general, these findings are consistent with those reported for the in situ dog muscle but are at variance with results of experiments with humans, especially the reports indicating substantial increases in O2 uptake during hypertoxic conditions.

Blood Glucose↗
PubMed1975

Outpatient alcohol detoxification: initial findings on 564 patients.

The authors report on a large-scale outpatient alcohol detoxification program, presenting a clinical rationale for outpatient detoxification, describing the program method, and giving initial evaluation data on the first 564 patients. Only 47 percent of the patients required detoxification, and only 19 percent of these required inpatient care. The majority of the patients successfully completed outpatient detoxification; half of these continued in the related rehabilitation program. There were no fatalities. The authors believe the results support the utility of outpatient detoxification as a cost-effective alternative to inpatient detoxification for the majority of acute alcoholics.

Acute Disease↗