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Biomedical subjects

T Greitz

Publications and source records attributed to T Greitz.

At least 55 records · Page 3Linked to original sources

External detection of axoplasmic flow using radionuclides.

In order to investigate the possibilities of studying the axoplasmic flow in vivo by means of radionuclide scanning 75Se-methionine was injected into the L6, L7 or S1 spinal ganglia of cats and the spread of the isotope recorded with a gamma camera. -2. After 4 hours the area of isotope distribution extended 1-2 cm cranially and caudally in the spinal cord and a further movement of 1-2 cm was noted during the following 2-5 days. -3. Scanning of removed specimens of the spinal cord, roots, ganglia and nerves confirmed the intramedullary uptake and in addition revealed an uptake in the dorsal root. Determination of the specific radioactivity showed the presence of the isotope in the ventral root and spinal nerve also, however, sufficient for scintigraphy. -4. Microautoradiographic studies with 3H-methionine demonstrated isotope uptake in axons of the dorsal roots and root entry zone of the spinal cord. Hence, the spread of the isotope was likely to have occurred by axoplasmic flow. This seems to provide a basis for further in vivo studies of this phenomenon.

Animals

Preliminary experiences with the EMI scanner.

Preliminary experiences of computed tomography of the head are reported in a material of 213 patients. The majority of examined lesions includes intracranial tumours and cerebrovascular lesions.

Arachnoid

Cerebral blood volume alterations during fractional pneumoencephalography.

Simultaneous and continuous measurements of the cerebral blood volume (CBV), cerebrospinal fluid (CSF) and blood pressure were carried out in six patients during fractional pneumoencephalography in order to examine intracranial volumetric interactions. Three patients (Group A) showed normal encephalographic findings, and in three patients (Group B) communicating hydrocephalus with convexity block was found encephalographically. In all patients the injection of air was followed by an immediate increase of CSF pressure and blood pressure and a concomitant decrease of CBV. The initial CSF pressure was invariably re-established within 3 to 3.5 min. During this time interval the CBV of the patients of Group B decreased significantly and 30 percent more than that of Group A. Furthermore, after restoration of the original CSF pressure, CBV returned to its initial level in all patients of Group A, whereas it remained unchanged or showed a further decrease in the patients of Group B. Removal of an amount of CSF corresponding to half of the amount of injected air was followed by a significant reactive hyperemic response in two normal patients. The intracranial volumetric alterations during fractional pneumoencephalography are discussed in detail with respect to the underlying physiologic mechanisms and are suggested as a model for acute and low pressure hydrocephalus.

Adult

Trends in the development of reconstruction tomography in neuroradiology.

Because of the new uses of CT, it is difficult to accurately forecast the future balance between it and conventional radiologic techniques. However, the relatively low frequency resolution of CT makes it unlikely that conventional radiology will be completely replaced. Photon noise and the iodine concentration of the contrast medium limit the size of the cerebral vessels which can be studied by CT. Thus angiography is likely to remain the method of choice for fine-detail study of these vessels. For optimal measurements and comparative studies, improved head fixation is required. Given precisely reporducible positioning, stereotaxic surgery and radiation therapy become a reality.

Computers

Stereotaxic computed tomography.

A method for stereotaxic computed tomography is described. A head fixation system has been devised enabling the exact transfer of information fromthe diagnostic coordinate system of the scanner to other therapeutic or diagnostic coordinate systems.

Computers

Stereotactic exploration of brain tumours by ultrasound.

A report upon a new technique for investigation of brain tumour anatomy by means of stereotactically directed ultrasound is presented with some illustrative cases. Information obtained with this technique has been found useful when deciding the treatment program for the tumour.

Brain Neoplasms

Myelography in metastatic lesions.

The radiologic appearances at gas myelography were analysed in 57 metastatic lesions, all histologically verified, or having known primary tumours. Five of these cases were also examined with a water-soluble contrast medium, metrizamide. The results were correlated to the findings at surgery and to tumour pathology. It is concluded that myelographic findings simulating juxtamedullary growth are usually due to local indentation of the dura by the extradural tumour, and not to intradural extension.

Adolescent

Computer tomography for diagnosis of intracranial tumours compared with other neuroradiologic procedures.

The diagnostic effectiveness of computer tomography has been assessed in a series of 361 patients with the primary clinical problem of a possible intracranial neoplasm. Of these patients, 171 were shown to have a tumour, confirmed at microscopy in 115 instances. Computer tomography was compared with other established neuroradiologic procedures, such as encephalography, angiography and isotope scanning, all of which were frequently used in this series of patients.

Brain Neoplasms

Computer tomography in post-mortem examination of the brain and other specimens.

A technique is described for post-mortem examination of brain specimens employing computer tomography, for accurate comparison with in vivo scanning, including subsequent cutting of specimens in sections corresponding to tomographic layers measured. Potential application of this technique to diagnosis of mammary tumours is discussed.

Autopsy

Computer intravenous angiography.

Computer tomography could be useful in demonstrating lesions of intracranial vascular structures. Experimental methods aimed at achieving this are presented and clinical examples using intravenous angiography are given. The factors involved by the demonstration of intracranial vessels are discussed.

Cerebral Angiography