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T Grieco

Publications and source records attributed to T Grieco.

4 recordsLinked to original sources

[Importance of dermatologic screening within the frame work of a general cancer prevention program].

BACKGROUND: Skin tumours represent about 11% of all the malignant neoplasms and their frequency is increasing annually. Skin tumours (melanoma, basal and squamous cell carcinoma, etc.) can be used for a good screening activity, but in relation to breast or cervix uteri cancer needs to be better defined. A test on a population of selected patients against skin malignant neoplasms has been carried out in our Centre. All of them had skin lesions and further checks were necessary. METHODS: The diagnostic protocol used in our Centre for Oncological Prevention uses the collection of anamnestic data and an objective examination. Between 1996 and 2000, 222 patients between the ages of 18 and 80 have been selected. All of them had suspected skin lesions. The patients were selected by the oncologist, particularly for pigmentation, asymmetry, irregular borders and heterogeneous colour of their skin lesions. Subsequently, the patients were sent for a further examination to the dermatologist oncologist, who on the basis of the objective dermatological examination with possible dermatoscopy, made a clinical diagnosis of the skin injuries or suggested surgical removal for the histological control of the same. RESULTS: Requested consultations: 222. Exami-nations made: 195. Patients considered: 190. Skin injuries examined: 190. The following skin lesions were identified: melanoma: 4 (2.1%) [2: I Clark level; 2: II Clark level]; basal cell carcinoma: 14 (7.37%); dermatofibrosarcoma: 1 (0.53%); keratoacanthoma: 1 (0.53%); dysplastic nevus: 4 (2.1%); actinic keratosis: 7 (3.68%); benign lesions: 159 (83.68%). CONCLUSIONS: These data were obtained by a screening program and it is therefore not a random study. This study shows interesting results because tumoral skin lesions and in particular melanoma were recognised at early stages. This is more than enough for us to create a specific screening program for skin lesions to cut down the rate of morbidity and mortality.

Adult↗

Basal keratinocyte subsets: ultrastructural and morphometric features.

Basal keratinocytes reportedly comprise two ultrastructurally recognizable populations, usually referred to as serrated basal keratinocytes (SBK) and non-serrated basal keratinocytes (NSBK). The former are responsible for dermal-epidermal anchoring, whereas the latter serve in epidermal turnover (stem cells). The size and shape of these cells were investigated by electron microscopy and computer-assisted morphometric analysis. The results showed that perimeters of both the nucleus and cytoplasm of NSBK were consistently smaller than those of SBK. The shape factor (contour index) was lower in NSBK, indicating a more regular membrane surface. Present quantitative results substantiate previous subjective reports on the ultrastructural differences between NSBK and SBK and provide additional evidence that the basal cell layer in human epidermis is actually made up of at least two types of morphologically distinct keratinocytes.

Epidermal Cells↗