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Biomedical subjects

T Griffiths

Publications and source records attributed to T Griffiths.

7 recordsLinked to original sources
PubMed1988

Randomized trial comparing aminoglutethimide with high-dose medroxyprogesterone acetate in therapy for advanced breast carcinoma.

A total of 218 postmenopausal patients were entered in a prospective randomized trial comparing aminoglutethimide (AG) and high-dose medroxyprogesterone acetate (MPA) as second-line hormonal therapy for advanced breast carcinoma. All responses were assessed by the criteria of the International Union Against Cancer. The response rates were 27% (29 of 106 patients) for AG and 31% (35 of 112) for MPA, but if stabilization of previously progressive disease is included, then the overall response rates were 51% (54 of 106) and 54% (61 of 112) for patients receiving AG or MPA, respectively. There was no difference in response to the two drugs at any site of disease, and the durations of response and survival were identical for the two drugs. The time to response was significantly shorter for patients treated with MPA (median, 8.7 wk) than for those treated with AG (median, 15.3 wk) (chi 2 = 9.96, 1 df, P = .0016). The percentage of patients experiencing toxic effects was equivalent in both arms, although the patterns and time courses of these effects were different.

Aminoglutethimide↗
PubMed1987

Evaluation of psychological treatment in primary care.

As clinical psychology services to primary care have grown considerably in recent years, several papers have examined the impact of such services. Benefits to patients following contact with the psychologist have been described, but the few studies which have used control groups have -not shown long-lasting effects. However, assessing the global effects of psychological treatment creates several methodological problems, and many of the studies have serious shortcomings in their use of sampling procedures and dependent measures. Clear results are unlikely to emerge from such studies because psychological treatment is not a single entity but encompasses a number of interventions for different types of problem. A more differentiated approach to evaluation is needed to assess the effectiveness of psychological treatment services in primary care.

Humans↗
PubMed1979

Interstitial cystitis.

Twenty histologically proven cases of interstitial cystitis were investigated in an attempt to find evidence of a possible autoimmune mechanism in its aetiology. HLA tissue typing was performed, autoantibody profiles were obtained, and a questionnaire of the patients' past history completed, especially with respect to other autoimmune conditions. An experiment was designed to test the effect of sodium cromoglycate on rat bladders. The results are discussed in relation to the management of patients with interstitial cystitis.

Aged↗