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Biomedical subjects

T Grimes

Publications and source records attributed to T Grimes.

5 recordsLinked to original sources
PubMed2003

Dynamics of viral and proviral loads of feline immunodeficiency virus within the feline central nervous system during the acute phase following intravenous infection.

Animal models of human immunodeficiency virus 1, such as feline immunodeficiency virus (FIV), provide the opportunities to dissect the mechanisms of early interactions of the virus with the central nervous system (CNS). The aims of the present study were to evaluate viral loads within CNS, cerebrospinal fluid (CSF), ocular fluid, and the plasma of cats in the first 23 weeks after intravenous inoculation with FIV(GL8). Proviral loads were also determined within peripheral blood mononuclear cells (PBMCs) and brain tissue. In this acute phase of infection, virus entered the brain in the majority of animals. Virus distribution was initially in a random fashion, with more diffuse brain involvement as infection progressed. Virus in the CSF was predictive of brain parenchymal infection. While the peak of virus production in blood coincided with proliferation within brain, more sustained production appeared to continue in brain tissue. In contrast, proviral loads in the brain decreased to undetectable levels in the presence of a strengthening PBMC load. A final observation in this study was that there was no direct correlation between viral loads in regions of brain or ocular tissue and the presence of histopathology.

Animals↗
PubMedDate not supplied

Emotionally disturbed children's reactions to violent media segments.

This study examined the reaction of children with a diagnosed disruptive behavior disorder (DBD) to violent movie scenes. Children without one of these disorders were tested as well. DBD children ranged in age from 8 to 12 years and were outpatients at The University of Kansas Medical Center's Department of Child Psychiatry. These children were diagnosed by a child psychiatrist as meeting Diagnostic and Statistical Manual of Mental Disorders (4th edition) (American Psychiatric Association 1994) (DSM-IV) diagnostic criteria for having at least one of three emotional disorders: attention-deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), and conduct disorder (CD). Results showed that the disordered children differed from the nondisordered children on several dimensions. This suggests that DBD children process the anti-social messages in violent movies differently from children without a psychiatric disorder. An unabated diet of antisocial media could have harmful effects on children with a psychiatric illness.

Affective Symptoms↗
PubMedDate not supplied

The reification of normalcy.

Many researchers who investigate the putative effects of violent television on normal children claim there is a lifetime sociopathic effect on many of the children who watch. There may be. But there is a prevailing assumption that because television can produce sociopathic effects in a laboratory, that it does outside the laboratory. In addition, uncritical assumptions of psychological normalcy among most viewers are so prevalent among researchers in this field that any pathological lifetime effect may be exaggerated. The incidence of psychopathology, especially among nonrandom subject samples obtained from public schools, may be higher than investigators suspect, which could lead to overestimates of pernicious effects by television on children. Because pathological children are more vulnerable to commercial television's putative sociopathic effects than are normal children, they may bias study results toward sociopathic attitudes and behaviors, thus misleading researchers into believing that television has a greater sociopathic effect on normal populations than it actually has. Those psychopathologies are reviewed and prospective remedies are suggested for helping those children cope with the possible sociopathic effects of violently oriented television.

Adaptation, Psychological↗