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T Gualtieri

Publications and source records attributed to T Gualtieri.

4 recordsLinked to original sources
PubMed2001

The yeast cell-wall salvage pathway.

The integrity of the cell wall depends on the synthesis and correct assembly of its individual components. Several environmental factors, such as temperature up-shift, treatments with mating factors or with specific cell wall-perturbing drugs, or genetic factors, such as inactivation of cell wall-related genes (for example FKS1 or GAS1) can impair construction of the cell wall. As the cell wall is essential for preserving the osmotic integrity of the cell, several responses are triggered in response to cell-wall damage. This review focuses on the activation of salvage pathways that guarantee cell survival through remodeling of the extracellular matrix. These researches have useful implication for the study of similar pathways in human fungal pathogens, and for the evaluation of the efficacy of new antifungal drugs.

Calcineurin↗
PubMed1986

Methylphenidate and exercise: additive effects on motor performance, variable effects on the neuroendocrine response.

It has been suggested that the effects of intensive environmental stressors and of psychostimulant drugs may be interchangeable. A specific test of this hypothesis was undertaken in a double-blind, placebo controlled, cross-over study of the stimulant drug, methylphenidate (MPH), and of intense exercise, alone and in combination. On measures of motor performance the effects of MPH and of exercise were additive while on measures of neuroendocrine response the individual and interactive effects were variable. The effects of MPH and of intense exercise are probably mediated by mechanisms that overlap to a degree but are by no means identical.

Adolescent↗
PubMedDate not supplied

The delayed neurobehavioural sequelae of traumatic brain injury.

This is a comprehensive review of the late-occurring effects of traumatic brain injury (TBI). It appears that TBI increases the risk over basal rates for the general population, to this degree: for depression, by a factor of five or 10; for seizures, by two to five; for psychotic disorders, by the same factor; and for dementia, by four or five. Severe TBI, or injuries with special characteristics, may increase the risk of delayed sequelae even further. One is not able, at this point, to estimate the relative occurrence of a newly described entity--delayed amnesia. An initial TBI increases the risk for subsequent TBI, by a factor of two. A second TBI increases the risk of yet another TBI eightfold.

Amnesia↗