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Biomedical subjects

T H Bryson

Publications and source records attributed to T H Bryson.

5 recordsLinked to original sources
PubMed1987

Pre-oxygenation and the parturient patient.

The effects of pre-oxygenation were studied by continuous expired oxygen analysis in twenty pregnant patients and ten nonpregnant controls. The Magill system and a demand valve breathing system were both studied with tidal and vital capacity breathing. Rapid pre-oxygenation was possible with the demand valve system but the technique was associated with air leaks around the mask. Vital capacity breathing with the Magill system was inefficient in practice because of rebreathing and air leaks, and the recently proposed four vital capacity breath technique provided suboptimal alveolar oxygenation in pregnant subjects. Oxygenation in pregnant subjects was significantly faster than in nonpregnant controls and was achieved after just 2 minutes of tidal breathing from a standard Magill system with a prefilled reservoir. Care was necessary to ensure a gas-tight seal around the facemask.

Adult↗
PubMed1983

Single dose suxamethonium and muscle pain in pregnancy.

The frequency of muscle pain was studied in two groups of patients. One group consisted of 106 women undergoing Caesarean section; the other comprised 20 pre-menopausal women undergoing hysterectomy. Both groups received a single bolus injection of suxamethonium 100 mg to facilitate tracheal intubation. There was a statistically significant decrease in the frequency of muscle pain in the pregnant group (7.5%) compared with the non-pregnant group (30%).

Adult↗
PubMed1976

Intradermal study of a new local anaesthetic agent aptocaine.

In a double-blind trial in 28 human volunteers, a new local anaesthetic agent, aptocaine, was compared intradermally at 1, 2 and 3% concentrations with lignocaine 2% and bupivacaine 0.5%. In a second trial in 27 subjects, 1% aptocaine was compared with mepivacaine and prilocaine, both 1, 2 and 3%. In terms of activity as determined by area of anaesthesia, and of duration of action, aptocaine was similar to mepivacaine and more active and long-lasting than lignocaine and prilocaine. By this route aptocaine also appeared longer-lasting than bupivacaine. Duration of action was unaffected by concentration. Aptocaine had marked vasoconstrictor activity, which was maximal at 1%. These local anaesthetic properties suggest that aptocaine merits clinical trials, especially in dentistry.

Adult↗