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T H Frost

Publications and source records attributed to T H Frost.

10 recordsLinked to original sources

Female sexual assault: medical and legal implications.

STUDY OBJECTIVE: To assess the medical and legal effectiveness of this institution's existing adult female sexual assault protocol. DESIGN: Retrospective review. SETTING: Urban public hospital. TYPE OF PARTICIPANTS: One hundred eighty-two adult female sexual assault victims undergoing evaluation within 36 hours of assault. MEASUREMENTS AND MAIN RESULTS: Each case was reviewed with specific attention to associated injuries, sexually transmitted disease, compliance with medical follow-up, pregnancy, and legal outcome. Half of all cases had associated injuries. Nine percent of the women were found to have genital trauma on pelvic examination, although only 29% of these women had complaints of genital pain or bleeding. Ten percent of all women had positive gonorrhea cultures at initial examination. Thirty percent of the women completed the follow-up protocol. None of the women given postcoital estrogen therapy is known to have become pregnant. Only 53 of the 182 cases had the potential for successful prosecution with both a victim willing to cooperate in prosecution and an identified assailant. Thirty-four percent of these cases resulted in a successful prosecution. Evidence of genital or nongenital trauma was significantly associated with a successful legal outcome. CONCLUSION: A physical and evidentiary examination, including pelvic examination and assays for sperm and acid phosphatase, is warranted in all cases of female sexual assault presenting within 36 hours of the assault. Institutions dealing with victims from a transient, lower socioeconomic population should offer prophylactic treatment for sexually transmitted disease and pregnancy rather than rely on compliance with follow-up schedules.

Adolescent

Kinetics of hemodialysis: a theoretical study of the removal of solutes in chronic renal failure compared to normal health.

A theoretical comparison of various treatment strategies for the dialysis of patients with chronic renal failure has been made covering a wide mol wt spectrum (60 to 5250 daltons) of metabolites. A two-compartment model has been used with the generation rate in the appropriate pool. The comparison for any given metabolite is made, keeping the same level of predicted intracellular concentration as in traditional Kiil treatments, and it is found that the number of treatment hours per week may be reduced pro rata as the dialyzer clearance is increased. This result is independent of the assumed site of metabolite generation, of the distribution volumes, and of the level of the cell wall permeability. The cyclic fluctuation in intracellular concentration and the mean level of intracellular concentration, in relation to the level in normal health, are both predicted for a given metabolite to be lower if thecell wall permeability is assumed to be on the low side rather than on the high side. The clinical implications of the variations in intracellular and extracellular concentration are discussed, and considerable elevation compared to normal health is predicted for both compartments for large molecules, larger than or equal to 1,000 mol wt, which are generated effectively in the extracellular compartment.

Humans

Which dialyser?

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Blood Flow Velocity

Permanent neurological sequelae despite haemodialysis for lithium intoxication.

THREE PATIENTS WITH LITHIUM TOXICITY ARE REPORTED, TWO OF WHOM WERE EXPOSED TO TOXIC LITHIUM LEVELS FOR A PROLONGED PERIOD: both survived with permanent damage to basal ganglia and cerebellar connexions despite effective lowering of lithium levels by haemodialysis. Data obtained during dialysis treatment show prolonged haemodialysis to be the treatment of choice. If facilities for haemodialysis are not available or the patient presents with toxic lithium levels and minimal symptoms peritoneal dialysis will effectively lower serum lithium levels, but more slowly than haemodialysis.

Basal Ganglia

Disposable membrane insert for the Kiil dialyser.

The use of a presterilized, disposable, mesh-supported membrane envelope in the Watson Marlow Kiil dialyser results in a 12% improvement in urea and creatinine clearance. Priming volume, uptake volume, and ultrafiltration rate are unchanged. Residual blood volume remains small. Blood flow resistance is increased. The envelope therefore offers considerable advantages over conventional assembly for dialysis with a blood pump.

Creatinine