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Biomedical subjects

T H Guthrie

Publications and source records attributed to T H Guthrie.

At least 37 records · Page 2Linked to original sources
PubMed1985

Chemotherapy of eyelid and peritorbital tumors.

Eight patients with nine histologically proven BCC or SCC involving the eyelids and periorbital tissues were treated with systemic and/or local (iontophoresis) chemotherapy using cisplatin and doxorubicin. All patients had either refused surgery, would have required extensive procedures, or had medical problems contraindicating surgery. Systemic chemotherapy induced a CR or PR in eight of nine lesions. No patient has required maintenance chemotherapy and no significant toxic side effects were encountered. The length of follow-up ranges from 2 to 50 months. Iontophoretic therapy with cisplatin was used to treat five small foci of new, recurrent or persistent tumor(s) in three of these patients, and resulted in a partial response in all five lesions. Systemic or local chemotherapy offers an alternative to current standard forms of treatment for BCC and SCC in selected cases.

Aged↗
PubMed1984

Hypertrophic pulmonary osteoarthropathy heralding relapse of lymphoepithelioma.

Hypertrophic pulmonary osteoarthropathy is an uncommon paraneoplastic syndrome occasionally associated with nasopharyngeal lymphoepitheliomas. We treated two patients with previously diagnosed lymphoepitheliomas in whom hypertrophic pulmonary osteoarthropathy preceded the recognition of pulmonary metastases. Both patients' disabling arthritic syndromes resolved with effective therapy directed at their neoplasms.

Adolescent↗
PubMed1984

Breast cancer concepts.

Surgery is the primary treatment for early breast cancer. Several studies have shown that routine postoperative radiation therapy does not increase patient survival. Chemotherapy is currently recommended as an adjuvant to mastectomy in patients with positive axillary nodes. Patients who have recurrent disease and tumors that are hormone-receptor-negative, or tumors that are unresponsive and hormone-receptor-positive, are receiving significant survival benefits from combination chemotherapy.

Adenofibroma↗
PubMed1983

Brief communication: Legionnaire's disease successfully treated in acute myelocytic leukemia during severe neutropenia.

A patient with acute nonlymphocytic leukemia developed progressive lung infiltrates and unremitting fevers during a profound neutropenic state. Legionnaire's disease was diagnosed by simple immunologic studies and successfully treated with erythromycin. This index case alerts physicians toward a treatable infection which would not normally be susceptible to the empiric antibiotic regimens given neutropenic patients with fevers.

Agranulocytosis↗
PubMed1983

Pure red cell aplasia obscured by a diagnosis of carcinoma.

Three cases of pure red cell aplasia (PRCA) associated with carcinoma, previously considered a rare paraneoplastic syndrome, are reported. Two cases responded to steroid therapy. In two the diagnosis of PRCA was obscured by the carcinoma until bone marrow examination revealed the true cause of the anemia. These three cases once again support routine bone marrow examination to determine the cause of anemia, regardless of other medical problems.

Aged↗
PubMed1983

Treatment of L-asparaginase allergic reaction.

The treatment of an allergic reaction to L-asparaginase is discussed in the presentation of a case of a 26-year-old man with chronic myelogenous leukemia who was undergoing methotrexate-L-asparaginase rescue therapy. The possible mechanism of action of L-asparaginase is reviewed, and precautions for use of L-asparaginase in combination therapy with methotrexate are presented.

Adult↗
PubMed1983

Abnormal liver-spleen scan associated with hyperviscosity syndrome.

A patient with hyperviscosity syndrome was noted to have an abnormal liver radionuclide scan. Ultrasound and normalization of the liver scan after plasmapheresis confirmed the non-neoplastic nature of the patchy labeling defects. This case suggests a new cause for labeling abnormalities on liver radionuclide scans in patients with a syndrome where liver biopsies would be unusually hazardous. Possible mechanisms for this scintigraphic pattern in the hyperviscosity syndrome are briefly discussed.

Aged↗
PubMed1983

Male germ cell tumors.

New treatment approaches to male germ cell tumors have produced dramatic improvements in both survival and cure rates. The traditional use of surgery and radiation therapy for all male germ cell neoplasms has given way to individualized therapy based on histology, stage and the serum tumor markers. Cure rates of 95 percent for seminomas and 80 percent for nonseminomatous germ cell tumors are now achieved.

Adult↗
PubMed1982

Amyloidosis masquerading as inflammatory bowel disease with a mass lesion simulating a malignancy.

Our patient, who was known to have multiple myeloma, presented with weight loss, rectal bleeding, and a barium enema study suggestive of a colitis with a mass lesion. Colonoscopy with biopsy revealed the mass to be large mucosal folds infiltrated with amyloidosis. Amyloidosis has been reported to mimick malignancy, mainly by tumorous deposits in the stomach and less commonly in the small and large bowels. Gastrointestinal surgery in patients with amyloidosis potentially may have undesirable consequences due to failure of anastomotic suture lines and subsequent sepsis (6, 11, 17, 18). The knowledge that amyloidosis may be associated with multiple myeloma and an appreciation of the wide range of gastrointestinal roentgenographic findings in patients with amyloidosis should prompt the clinician to obtain endoscopic and biopsy evaluation of these patients.

Adult↗
PubMed1980

Emergency care of the hemophiliac patient.

Hemophilia is a congenital disorder characterized by prolonged bleeding, many times in association with little or no trauma, in which proper treatment may save lives or prevent permanent sequelae. We report an illustrative case and review the management of common problems with which a hemophiliac might present to the emergency department.

Adult↗
PubMed1975

Cerebral cysticercosis.

Cerebral cysticercosis is a neurologic disease with myriad manifestations. Three basic types of infections occur: localized, widespread, and proliferative inflammatory reaction. A case is reported illustrating the first type of infection and one type of clinical presentation,--focal seizures. The worldwide distribution of the disease suggests that as global travel increases we will have to consider the diagnosis more often. The diagnosis is established principally through thorough examination of the CSF plus signs of parasitosis in other parts of the body. A history of living in an endemic area should strengthen suspicion. Definitive treatment is currently limited to neurosurgical intervention.

Adult↗