Biomedical subjects
T Hager
Publications and source records attributed to T Hager.
[Rectum prolapse: resection or abdominal rectopexy].
From January 1983 to December 1987 38 patients had an operation for rectum prolapse. Out of them 20 had anterior rectal resection, in 16 cases we performed a Ripstein-operation, in 1 case we had to do a Miles-procedure, in 1 case a Hartmann-procedure. The follow-up of the patients with anterior rectal resection showed significant increase of continence. There was no recurrence, no patient died from the operation. The Ripstein-procedure showed less effectiveness concerning the continence. In this group we found recurrences, no patient died due to the operation. There was no infection in the small pelvis. We now prefer the anterior resection for treatment of rectum prolapse. First of all we had no recurrence and we were able to increase the continence. This is reason enough to treat the rectum prolapse further on by anterior rectal resection.
Non-invasive quantitative estimation of bone density in rats throughout the life cycle and in arthritic osteopenia: preliminary results.
A longitudinal bone survey was conducted in 86 female Wistar rats in order to assess mineral density kinetics from young age (5 weeks: 115 g) till late adulthood (64 weeks: 586 g). In vivo quantitative radiographic scanning was performed on the caudal vertebrae, taking trabecular mass as the parameter. Measurements were expressed as Relative Optical Density (ROD) units by means of a high resolution densitometric device. Results showed a progressive increase in mineral density throughout the life cycle, with a tendency to level in the higher weight range, indicating that progressive mineral aposition occurs in rats in dependency of age. This phenomenon, however, should be always considered within the context of continuous skeletal growth and related changes typical of this species. Twelve different animals were also examined following induction of articular inflammation with Freund's adjuvant in six of them. Bone survey conducted 12 to 18 days after inoculation revealed a significant (P less than 0.01) reduction in trabecular bone mass of scanned vertebrae in comparison with the weight-matched untreated controls. It is concluded that the in vivo quantitative assessment of bone density illustrated in this report represents a sensitive and useful tool for the long-term survey of naturally occurring or experimentally induced bone changes. Scanning of the same part of the skeleton can be repeated, thereby avoiding sacrifice of the animal and time-consuming preparation of post-mortem material.
High-risk 'heart' families: a genealogical look.
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Obesity drug, genetic studies renew hope for autism therapy.
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The interferon-cancer trials: hardly hopeless but not too heartening.
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'Pacemaker' studied for impotence.
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For the future: polymer-drug systems.
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What is role of factor VIII therapy in inducing helper suppressor ratio reversals in hemophiliacs?
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New surgical techniques ease incontinence.
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Cigarettes pose dual threat in emphysema.
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Local excision of cancer of the rectum.
Local excision of rectal cancer can be a part of treatment of this tumor. The authors do not feel that this procedure is only palliative. Clinical staging I and II, tumor diameter less than 3 cm, malignancy grade 1 or 2, invasion no deeper than the submucosa, and no signet-cell carcinoma are all requisites for limited, local excision of rectal carcinoma. Patients operated upon under these criteria have a five-year survival rate of 89.6 +/- 21.7 per cent for those with invasion into the submucosa and 78 +/- 49.9 per cent for those with invasion into the muscularis propria. But to get such good results, strict self control must be exercised in selecting patients.
Cancer drug sensitivity test has problems.
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Update: photoradiation therapy for cancer.
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[Diagnosis and therapy of hemorrhoids].
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[Computed Axial tomography in patients with abdomino-perineal excision. A radiological and clinical control (author's transl)].
From 1978 to 1980 a total of 119 patients with carcinoma of the rectum were treated by abdominoperineal excision at Erlangen University Surgical Clinic. 66 of these patients were examined by CAT scan in a follow-up study. Local recurrence was found in nine patients. A radical second operation was useful in one case only. Our findings show, that only postoperative check-ups by CAT scan can detect new tumor growth at an early state. The prognostic groups used in Erlangen are helpful in defining the intervals for postoperative examinations by CAT scan.
[Surgery of Crohn's disease: a study of 155 patients after intestinal resection (author's transl)].
Operative mortality after intestinal resection in 155 patients with Crohn's disease was 8.4%. In 12 of 13 the cause of death was septic complications, most of them related to prolonged pre-operative cortisone medication. Follow-up examination was possible in 90% of all discharges. Five-year recurrence rate was 37.6%. Recurrence was not prevented by long-term drug treatment. Purely macroscopic assessment of the resection margins would have led to excision within diseased gut: for this reason frozen sections are recommended before the anastomosis is made. Primary death-rate in 30 cases of colectomy with primary ileorectostomy was 3%. In three patients the rectum had to be excised, while in one the anastomosis had to be taken down because of recurrence. The failure rate was thus only 11%. If rectoscopy, stepwise biopsy and intra-operative frozen section indicate a normal rectum it is recommended that ileorectostomy be done rather than diversion ileostomy with occlusion of the rectum or even proctocolectomy.
[Frequent anal and perianal disorders and their treatment].
Anal fissures, internal hemorrhoids and perianal thromboses are very common and frequent diseases. Diagnosis is simple even with limited experience in endoscopy. Treatment of the anal fissure consists in slow dilatation with a bougie in cases of acute fissues if the sphincter internus muscle is not highly spastic, in cases of chronic or very painful acute fissures a posterior or lateral sphincterotomy should be performed. Hemorrhoids can be treated with different methods, the optimal conservative treatment is by injection of phenol. In cases of prolapsing hemorrhoids an operation should be performed. Perianal thromboses should be opened by incision. The different methods of treatment are described.