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T Hallynck

Publications and source records attributed to T Hallynck.

10 recordsLinked to original sources
PubMed1983

Reproducibility study of the pharmacokinetics of amikacin, gentamicin and tobramycin; a three-way crossover study.

The hypothesis that the pharmacokinetics of amikacin are more predictable than those of gentamicin or tobramycin was studied. In a three-way crossover design 58 volunteers received 7.5 mg/kg amikacin by iv infusion and either 1.5 mg/kg or 1 mg/kg gentamicin and tobramycin. The mean half-life and mean serum concentration at 1 h for each drug was determined. No consistent significant difference was found between the pharmacokinetics of amikacin and the other two drugs.

Amikacin↗
PubMed1982

An evaluation of the homogeneous substrate-labeled fluorescent immunoassay for tobramycin in serum.

The homogeneous substrate-labeled fluorescent immunoassay for tobramycin in serum was evaluated. Standard curves are linear and reproducible. The within-run coefficient of variation for control samples containing low, medium and high concentrations of tobramycin ranged from 1.9 to 6.5%; the between-run coefficient of variation was 11% for a control sample at low concentration. The accuracy measured on spiked samples was good and comparable to the accuracy measured by a microbiological assay; it was somewhat better than for the radioimmunoassay. For patient samples, the results with this method correlated well (r - 0.914) with results obtained by radioimmunoassay.

Anti-Bacterial Agents↗
PubMed1981

Prediction of creatinine clearance from serum creatinine concentration based on lean body mass.

An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentration is presented. The predictions are compared with four other available estimating methods, bases on values in 110 subjects with renal impairment of widely differing degrees. In patients with stable and with unstable renal function the corelaion between measured and predicted CrCl was better with the new equation. In patients with rapid changing renal function the new equation resulted in accurate predictions CrCl within a few hours after the change, as opposed to several with the other methods. The elimination rate constant of the aminoglycoside antibiotic amikacin correlated more precisely with CrCl values estimated from the new equation that with those measured doing 24 hr or with the other prediction methods.

Acute Kidney Injury↗
PubMed1980

[Comparison of methods of determination of serum doxycyline assessing relative bioavailability of two commercial formulations (author's transl)].

The present study was undertaken to evaluate the accuracy of the analytical results of an investigation of relative bioavailability of two doxycycline preparations. Six methods in four laboratories were applied: one fluorimetric, three high-pressure-liquid-chromatographic and three microbiological methods. The analyses were performed after coding the samples. In all cases the two preparations were bioequivalent. When comparing the methods, it could be shown that the fluorimetric method was slightly more accurate than the others. The HPLC-methods were almost as accurate. The results of the microbiological determinations showed the lowest accuracy. Two of the results were in good agreement with the biochemical methods, whereas the third showed such a high deviation that a comparison was no longer possible. Altogether a good agreement of all compared methods (except one) could be demonstrated.

Biological Assay↗
PubMed1976

Pharmacokinetics of amikacin in patients with renal insufficiency: relation of half-life and creatinine clearance.

The half-life of amikacin after a single intramuscular injection was determined in patients with severe renal failure who received 3.75 mg of drug/kg and in patients with various degrees of renal function who received 7.5 mg of drug/kg. The relation of the half-life of amikacin to levels of serum creatinine is practically identical to that of kanamycin. However, although concentrations of serum creatinine remained practically unchanged, rates of creatinine clearance may by considerably decreased in older subjects. This decrease may result in overestimation of the rate of glomerular filtration and subsequent overdosage. Therefore, the half-life of amikacin should be derived from values of rates of creatinine clearance or be predicted with use of a nomogram. The calculated half-life values may be used for development of appropriate dosage schedules for patients with various degrees of renal function. Such schedules would ensure therapeutic levels of drug and avoid potentially toxic accumulation of antibiotic.

Aged↗