Biomedical subjects

T Han

Publications and source records attributed to T Han.

At least 235 records · Page 13Linked to original sources

PubMed1975

Specific effect of neuraminidase on blastogenic response of sensitized lymphocytes.

The blastogenic response of sensitized lymphocytes from guinea-pigs to 'de novo' antigens (KLH, HCH and PPD) was ehhanced by BCN treatment in twenty-one of twenty-three instances. In contrast, no effect of VCN on nonsensitized guinea-pig lymphocyte response to these antigens, or to mumps antigen, was noted in any of thirty-four instances, These findings indicate that the enhancement effect of VCN is specific for sensitized lymphocytes. Heating VCN at 100 degrees for 10 minutes completely abolished the enhancement effect on the lymphocyte response. VCN treatment did not change the kinetics of antigen-induced blastogenesis. The increased lymphocyte response could probably be related to unmasking of the antigen receptor sites of the cells, resulting in increased antigen uptake, following the VCN treatment.

Animals↗

PubMed1975

In vitro transfer of tumour-specific immunity with human 'immune' RNA.

In vitro tumour-specific immunity against lung cancer was passively transferred in the leucocyte migration inhibition system with 'immune' RNA in man; 'non-immune' RNA, on the other hand, failed to transfer such immunity, indicating the specificity of 'immune' RNA.

Antigens, Neoplasm↗

PubMed1975

Disparity of mixed lymphocyte reactivity to cultured cells of human T and B lymphoid lines.

Repeated attempts with difference assays and experimental conditions failed to detect significant peripheral blood lymphocyte reactivity in one-way mixed lymphocyte reactions to irradiated or mitomycin C-treated cells of the "leukemic" T lymphoid line RPMI 8402. In contrast, consistently high levels of peripheral blood lymphocyte reactivity were obtained with cells of six B lymphoid lines established from the same blood sample used to initiate this T lymphoid line. Although attempts to define the reason why these cultured T cells did not initiate a mixed lymphocyte reaction were not successful, evidence indicates that this inability may be an intrinsic characteristic common to three other T lymphoid lines (MOLT-4, CCRF-CEM, and CCRF-HSB-2), also established from patients with relapsed acute lymphoblastic leukemia.

B-Lymphocytes↗

PubMed1974