Gene repression paradigms in animal cells.
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Animals↗
Biomedical subjects
T Hashimshony
Publications and source records attributed to T Hashimshony.
An upstream repressor element plays a role in Igf2 imprinting.
The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a trans- acting factor, GCF2. DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo.
Animals↗
DNA methylation models histone acetylation.
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Acetylation↗