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Biomedical subjects

T Hashizume

Publications and source records attributed to T Hashizume.

At least 253 records · Page 14Linked to original sources
PubMed1979

Protective effect of cetraxate, a new antiulcer drug, against serotonin-induced ulcer.

Cetraxate increased gastric mucosal blood flow and inhibited the decrease in blood content of the rat gastric preparation, as induced by serotonin. In addition, this compound decreased the inside pressure of the rat stomach and the tone of the rat fundus strip and inhibited the increase in gastric emptying rate induced by serotonin. Further effects of the drug were decrease in the tone of isolated rabbit aorta and inhibition of platelet aggregation as induced by thrombin. Decrease in the vascular resistance was apparently related to increase in the gastric blood flow. These experimental results suggest that the antiulcer effect of cetraxate is due to the improvement of blood circulation in the gastric mucosa.

Animals↗
PubMed1978

Pharmacological and histological studies of gastric mucosal lesion induced by serotonin in rats.

Serotonin in doses of 5 to 80 mg/kg injected subcutaneously to rats injured the gastric mucosa dose-dependently and the lesion was histopathologically regarded as erosion. Aggregated platelets were observed in small blood vessels of the gastric mucosa prior to the development of erosion when serotonin was injected in a subcutaneous dose of 20 mg/kg effective in producing the lesion. Subsequently fibrinous thrombi could be found in the lesional mucosal area at the stage of erosive change. Serotonin in the same dose decreased gastric mucosal blood flow and enhanced gastric motility in the peroid of time when pre-erosive or erosive change occurred. Circulatory disturbance of the gastric mucosa induced by these histological and functional changes seemed to play an important role in development of the gastric mucosal lesion by serotonin. It is unlikely that gastric acid takes part as a trigger in producing the lesion.

Animals↗
PubMed1976

Electron impact-induced reactions of N6-(3-methyl-2-butenyl)adenosine and related cytokinins.

Fragmentation reactions of the biologically important N6-(3-methyl-2-butenyl)adenyl moiety have been re-examined with the aid of systematic deuterium labeling in the sidechain and by examination of the 1- and 7-deazanucleoside analogs. It is concluded that the diagnostic reactions which involve expulsion of C3H7 proceed predominantly by ring closure from the sidechain double bond to N-1 (ion a). Base-containing ions m/e 135 and 148 were confirmed to arise mainly by rearrangement of hydrogen from the methyl terminus to N6 and simple cleavage, respectively, but with significant contribution from other pathways involving transfer of sidechain hydrogens to the base.

Adenosine↗