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Biomedical subjects

T Healey

Publications and source records attributed to T Healey.

At least 19 recordsLinked to original sources
PubMed2002

Tissue levels, histologic changes and plasma pharmacokinetics of meta-Tetra (hydroxyphenyl) chlorin (mTHPC) in the cat.

The biodistribution and pharmacokinetics of meta-tetra(hydroxyphenyl)chlorin (mTHPC)(1) have been documented in humans, rats, dogs and rabbits. It has been demonstrated to be an effective photodynamic therapy agent for treatment of squamous cell carcinoma. Squamous cell carcinoma is a common feline neoplasm, causing significant morbidity and mortality in the feline population. The association between ultraviolet radiation exposure and occurrence of this neoplasm in the cat provides a useful model for the study of human cutaneous squamous cell carcinoma. In this study, we document the biodistribution, pharmacokinetics and toxicity of mTHPC in a group of normal cats. Four groups of cats were given the drug intravenously at dosages of 0, 0.15, 0.30 and 0.60 mg/kg. mTHPC levels were measured in plasma and tissues at 0, 24, 48, 72, 96 and 336 h after drug administration. Additionally, plasma samples were collected at 1 and 6 h post-injection and analysed. Biodistribution and pharmacokinetics of mTHPC in cats mirrors that in other animal species. There were no clinical or pathological changes associated with administration of the drug. The biodistribution and pharmacokinetics of mTHPC in cats mirrors that in other species studied. There were no clinical or pathological changes attributable to administration of the drug at the doses administered. mTHPC may be a useful photodynamic therapy drug in cats.

Animals↗
PubMed1998

A report on the Council on Certification 1996 Professional Practice Analysis.

The purpose of this article is to provide an overview of the Council on Certification of Nurse Anesthetists 1996 Professional Practice Analysis. This analysis was used to update the previous content validation studies. Surveys were mailed to a select group and a practitioner group of 2,859 Certified Registered Nurse Anesthetists with a response rate of 63.7%. Respondents were asked survey questions related to demographics, practice settings, education, and fundamental knowledge related to nurse anesthesia practice. Respondents were asked for the frequency and level of expertise related to patient conditions, procedures, anesthesia agents and techniques, equipment, instrumentation, and technology of anesthesia practice. The results for both groups were consistent with the previous studies. The Rasch rating scale model was used to transform the results from ordinal data onto a linear, equal-interval scale. Members of the Council on Certification of Nurse Anesthetists carefully reviewed all of the Professional Practice Analysis results and voted to maintain the current test blueprint and percentage of test items in each area.

Certification↗
PubMed1996

A two-year follow-up of neonates with presumed sepsis treated with recombinant human granulocyte colony-stimulating factor during the first week of life.

We have previously reported that recombinant human granulocyte colony-stimulating factor was well tolerated and resulted in sustained neutrophilia and improvement of neutrophil functions in newborn infants with presumed sepsis. We now report a 2-year follow-up on 21 of the initial cohort of 28 patients. Treatment with recombinant human granulocyte colony-stimulating factor in neonates with presumed sepsis was not associated with any long-term adverse hematologic, immunologic, or developmental effects.

Blood Cell Count↗
PubMed1988

The quantification of synthetic corticosteroids using isotope dilution gas chromatography negative chemical ionization mass spectrometry.

Prednisolone, dexamethasone and betamethasone were labelled with deuterium via a simple synthetic procedure and used as internal standards in the gas chromatographic/mass spectrometric analysis of the corresponding undeuterated compounds. The mass spectrometer was used in the negative chemical ionization mode, which gave fragmentation of the methoxime trimethylsilyl ether derivatives favourable for their quantification. The method was applicable to the quantification of synthetic corticosteroids contained in human aqueous humour in the 0.1-10-ng range.

Absorption↗
PubMed1985

Long-term follow-up of infants and children treated with extracorporeal membrane oxygenation (ECMO): a preliminary report.

Extracorporeal Membrane Oxygenation (ECMO) has been used clinically as a life-saving treatment modality in infants and children who are dying of respiratory insufficiency. From 1973 to 1980 47 children less than 10 years of age were treated in a study to determine the feasibility and effectiveness of ECMO in the pediatric population. Despite a predicted mortality of 90% or greater, 24 patients survived. Eighteen of those patients have been seen in long-term follow-up. Thirteen patients (72%) demonstrate basically normal growth and development. Five patients (28%) have definite handicaps which are severe in two. Despite ligation of one common carotid artery and systemic heparinization, the risk of intracranial hemorrhage and/or neurodevelopmental problems appears to be no higher in this ECMO group and may even be lower than in the high-risk population treated with conventional therapy. The incidence of chronic respiratory problems, especially bronchopulmonary dysplasia, is zero in this group of patients. Only one patient (4%) has a defect that lateralizes to the right hemisphere which may have been affected by ligation of the carotid artery. Further study is required; however, it appears that ECMO offers life-saving intervention without increasing morbidity in select children with severe respiratory insufficiency.

Adolescent↗
PubMed1984

Persistence of parathyroid hypersecretion after vitamin D treatment in Asian vegetarians.

An investigation into plasma calcium concentrations and the biochemical factors which regulate it in vegetarian Asian subjects without clinical or radiological features of osteomalacia revealed the presence of low serum 25-hydroxyvitamin D concentrations and elevated PTH concentrations, even in the presence of calcium levels in the normal range (up to 2.35 mmol/liter). These elevated PTH concentrations, though not as high as those in osteomalacic patients with hypocalcemia, often persisted despite treatment with vitamin D, normalization of 25-hydroxyvitamin D, and an increase in calcium concentrations. In one patient the PTH concentration remained high even when the plasma calcium concentration became supranormal. Therefore, secondary hyperparathyroidism is commonly associated with vegetarianism, and may play an important role in maintaining calcium concentrations within the normal range. Persistent elevation of PTH despite normalization of 25-hydroxyvitamin D also points to autonomous PTH hypersecretion, which may result in osteolysis in the long term, and raises the question of the need for vitamin D supplementation in vegetarians with low dietary intake of vitamin D.

25-Hydroxyvitamin D 2↗
PubMed1983

Identification from radiographs.

The identification of a radiograph as having been made from one particular person is an everyday task, usually undertaken by comparing an example with one or more of a previous series. Occasionally, the problem is to compare new views of human remains with radiographs of the same parts taken during life. Examples are reported wherein either procedure would have failed, as no significant differences were found in the bony or soft-tissue landmarks on chest radiographs of two sets of identical twins, aged 17 and 87 years. This may be a widespread phenomenon, not previously recognised from the rarity of twins presenting at the same time for the same examinations. Statements, based upon radiography, as to the identity of patients, must bear the caveat 'provided no identical twin exists'.

Adolescent↗
PubMed1980

Milk of calcium in calycine diverticula.

The so-called Milk of Calcium Renal Cyst is a rare condition wherein calcium salts in a fine suspension are retained in a calycine diverticulum. No treatment is indicated for this condition itself but it is sometimes complicated by stone formation or infection. Five cases are described.

Adult↗
PubMed1979

A calibration system for X-ray generators and tube factors.

An apparatus (Machlett's Dynalyzer II system) is described that makes real-time dynamic tests on the output and performance of the X-ray tube and generator so that a single exposure gives information on mA and mAs; exposure time (ms); kVp anode to earth; kVp cathode to earth; kVp cathode to anode; tube filament current; line voltage and radiation output of the tube (mR). The method of use is described together with the results of comparisons made with other test equipment. Some novel design features are of particular interest. The results show that by using this apparatus present design characteristics of X-ray generator-control-tube systems are such that the accuracy of calibration can be improved by at least an order of magnitude.

Calibration↗