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Biomedical subjects

T Helm

Publications and source records attributed to T Helm.

16 recordsLinked to original sources
PubMed2001

Evaluation of chronic urticaria in patients with Hashimoto thyroiditis.

The coincidence of Hashimoto thyroiditis (HT) and chronic idiopathic urticaria (CIU) is a commonly observed phenomenon in western New York. Previous literature suggested that there may be a direct relationship between them. We undertook these studies to determine whether humoral or cell-mediated mechanisms might link HT and CIU. Skin biopsies from patients with CIU, with or without HT, were indistinguishable by light microscopy. No immune complex deposition was observed, although only the skin from patients with CIU and HT contained perivascular fibrin deposits. Similarly, immunohistochemical studies evaluating cellular expression of CD3, CD4, CD8, CD20, and CD68 failed to differentiate between CIU with or without HT. Analysis of Vbeta restriction in thyroid tissue of patients with HT and the skin of patients with CIU and HT by in situ polymerase chain reaction failed to reveal any oligoclonal T-lymphocyte subpopulations. In contrast, only patients with CIU and HT had anti-FcepsilonRI antibodies in their sera that could induce degranulation of normal basophils. Some sera from patients with CIU and HT caused degranulation of normal basophils in the absence of anti-FceRI. The factor causing basophil degranulation in these sera was not determined. Patients with CIU and HT failed to improve clinically with thyroid replacement therapy. All CIU patients were equally well managed with symptomatic therapies. In conclusion, HT likely represents a marker of other autoimmunity, rather than being a direct causative agent in CIU. Management of CIU, with or without HT and with or without anti-FceRI antibodies, should be the same. Future studies will have to examine whether cell-mediated responses participate in CIU, especially in association with HT.

Adolescent↗
PubMed1998

Striate palmoplantar keratoderma: a clinical and ultrastructural study.

Palmoplantar keratodermas are poorly understood heterogeneous disorders of cornification. Autosomal dominant and autosomal recessive keratodermas with a varied clinical presentation are recognized. Striate keratoderma is uncommon. We report the case of a 15-year-old girl with keratoderma that began at 5 months of age. Her clinical and ultrastructural findings are reviewed. Routine microscopic examination revealed eosinophilic inclusions in the granular cell layer as well as prominence of the granular cell layer. Electron microscopic examination revealed corneocytes with an imbricated pattern. Ultrastructural findings in this unique case are contrasted with those of other palmoplantar keratodermas.

Adolescent↗
PubMed1993

Palisading cutaneous fibrous histiocytoma. An immunohistochemical study demonstrating differentiation from dermal dendrocytes.

The palisading cutaneous fibrous histiocytoma is a unique benign spindle cell tumor that often occurs in an acral location. Histologic findings feature nuclear palisading reminiscent of a schwannoma. Previous studies have suggested that this tumor may be a variant of a dermatofibroma. We performed immunohistochemical staining with a panel of antibodies including neurofilament, S100 protein, factor XIIIa, epithelial membrane antigen, Leu-7, desmin, and vimentin. We found positive staining with factor XIIIa and vimentin, suggesting connective tissue differentiation for this tumor.

Adult↗
PubMed1990

Caries among Danish schoolchildren in birth-cohorts 1950-78.

Data on caries prevalence are reported from 8- and 16-yr-old children living in a Danish community which established the Public Child Dental Health Service in 1957. Every fourth birth-cohort from 1950 through 1970 was followed longitudinally. In the 8-yr-olds, caries prevalence decreased in the primary dentition from 17 to 3 dmfs and in the permanent dentition from 3.4 to 0.3 DMFS over a 28-yr period. Among the 16-yr-olds, a reduction was observed from 16.4 to 5.1 DMFS over 20 yr. Time trends in the decreasing caries prevalence are related to various organizational events and preventive measures. Moreover, the possible influence of general changes in living conditions and health behavior is pointed out.

Adolescent↗
PubMed1990

Correlation between caries experience in primary and permanent dentition in birth-cohorts 1950-70.

Caries experience in the primary molars and canines at 8 yr of age and in the permanent dentition at 16 was correlated in every fourth birth-cohort between 1950 and 1970 in a Danish community. Correlations between 0.44 and 0.55 were found. Cross-tabulation of the data also revealed close association, but prediction of individual high caries risk children based solely on screening for caries experience in the primary dentition is hardly cost-effective.

Adolescent↗
PubMed1989

Contact urticaria and anaphylaxis to latex.

Contact urticaria and anaphylaxis to latex is reported in two patients. One case was associated with oral and vaginal exposure to a condom and the other with rectal exposure to a latex glove. Both patients had positive reactions to scratch or prick tests to pieces of latex, as well as latex radioallergosorbent test (RAST). The diagnosis of contact urticaria to latex is difficult to make on the basis of history alone.

Anaphylaxis↗
PubMed1989

[Association among general health, diet and need of dental care among retired pensioners living at home].

A pilot project was established in a Danish municipality with the aim of improving the nutrition of 67-85-year-olds living at home but who were dependent on domestic aid for purchasing or preparing their food. The project comprised health education and information concerning dietary habits as well as an offer of dental treatment to those who were physically or mentally handicapped. At initiation of the project, the persons (n = 110; 89% of the target population) were interviewed about their general and dental health, ailments, drug consumption, and diet. Furthermore, a clinical dental examination was made (n = 106). From these baseline registrations, the elderly were divided into subgroups: unbalanced, moderate, and balanced diet; low, moderate, and high consumption of, respectively, water/milk and coffee/tea; great, moderate, and no need for dental care. Systematic associations were found between general health problems and unbalanced diet. A tendency was observed toward more frequent complaints in the groups with relatively high consumption of water/milk and water/milk/coffee/tea. The strongest associations were found between general health complaints, handicaps, and masticatory deficiency on the one hand and great need for dental care on the other. Also, the group with great need for dental care was overrepresented in the group with unbalanced diet. It is argued that accessibility to dental care would improve the chances for the elderly to stay in their own homes.

Aged↗
PubMed1988

Changes in prevalence of approximal caries in 17-year-olds and related restorative treatment strategies over a 6-year period.

Two cohorts of 17-yr-olds treated in a municipal child dental service in 1978-79 and 1984-85 had bitewing radiographs taken at the examination before the last course of treatment in the service. All radiographs were read by one examiner, who did not know to which cohort the individual belonged. The subsequent treatment was recorded from the treatment records by another examiner, who was unaware of the results of the radiographic examination. According to radiographic scores, the proportion of decayed or filled (DFS) approximal surfaces had decreased from 23.2% to 17.4% during the period (difference: 25%). The proportion of unfilled surfaces which were decayed (DS) had remained almost constant, while 9.6% of the surfaces were filled (FS) in 1978-79 compared to 3.1% in 1984-85 (difference: 68%). Thus, in spite of a 25% decrease in total caries experience (DFS), a reduction of 68% would be claimed if fillings (FS) were interpreted as expression of disease prevalence. The risk of an approximal surface being filled decreased to about one fifth from 1978-79 to 1984-85, and the risk of being filled was nearly three times as high for approximal surfaces of children who already had approximal fillings at the time of examination. Thus, both the year of examination and the subject's previously received treatment seemed to influence the treatment strategy of the dentist.

Adolescent↗
PubMedDate not supplied

Fixed drug eruption from pamabrom.

A young woman presented with recurrent skin lesions that were predominantly perioral. Fixed drug reaction was diagnosed based on her history of intermittent ingestion of Pamprin, a common menstrual symptom reliever, and characteristic erythematous, pigmented, edematous patches. After oral challenge with two of the three ingredients in Pamprin, a diagnosis of fixed drug reaction to pamabrom was made. Pamabrom is a mild diuretic present in several over-the-counter and prescription menstrual symptom relievers. This is the first reported case of fixed drug reaction to pamabrom.

Adult↗