Biomedical subjects

T Henon

Publications and source records attributed to T Henon.

3 recordsLinked to original sources

PubMed1999

[Incomplete prescription: a potential medication error].

OBJECTIVE: According to the American Society of Health System Pharmacists, an incomplete or imprecise medial order comprises a prescription error. Such errors have potential consequences in terms of mortality, morbidity, prolonged hospital stay and, finally, in health care expenditure. The aim of this study was to determine the rate of incomplete prescriptions observed in a university hospital setting and identify the causes of such imprecisions. METHODS: A prospective analysis of prescriptions for oral medicines ordered by an internal medicine unit of a university hospital was conducted on a daily basis by a pharmaceutical team immediately after the orders were written. A complete prescription was defined as one with the following information: unit dose, formulation, number of doses per day, hour of administration, particular instructions for use. RESULTS: Among the 241 prescription lines analyzed during a 20 day period, 131 (54.2%) were incomplete. The number of doses per day was missing for 7.9%, unit dose for 6.2%, particular instructions for 4.9% and the formulation for 2.9%. DISCUSSION: These findings demonstrated the lack of quality of the prescriptions studied. A treatment scheme totally incompatible with quality prescriptions and a poor understanding of prescription quality were the most probable causes. These two elements reflect the gap between the outdated organizational scheme currently in use and appropriate implementation of the hospital drug distribution circuit.

Drug Prescriptions↗

PubMed1993

Cost effectiveness of thrombolytic treatment for myocardial infarction: comparison of anistreplase, alteplase and streptokinase in 270 patients treated within 4 hours.

Two hundred and seventy patients, under 71 years of age and suffering from a less than 4 h infarction diagnosed according to clinical and electrocardiographic criteria, were included: two 90-patient groups were randomized and then treated with either anistreplase (30 mg iv over 5 min) or alteplase (10 mg bolus injection + 5000 IU heparin bolus injection, followed by 90 mg alteplase over 3 h), and compared with a consecutive control series of 90 patients treated with streptokinase (1.5 million U over 1 h). Intravenous heparin and aspirin (250 mg day-1) were then prescribed routinely. The three groups were comparable as regards age (55.2 +/- 10 years), male/female ratio (10.4), the site of the infarction (42% anterior, 55% inferior) and initial clinical seriousness (Killip I = 90%, II = 8%, III = 2%). The patients were thrombolysed in 17 community hospitals, and then referred to a university hospital with catheterization facilities. An efficacy score was determined, based on four parameters: two obtained from coronary angiography and left ventriculography performed on day 6 +/- 2 (N = 252) (asynergic score and patency of the infarct-related artery), one from Tl-tomography performed at rest (infarct size) and one from radionuclide angiography (global left ventricular ejection fraction) performed between day 15 and day 21 (N = 242). The score (range: 0-24 per patient) was 17.8 +/- 6.4 for alteplase, 17.7 +/- 6.0 for anistreplase and 18.1 +/- 6.0 for streptokinase respectively (NS).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMedDate not supplied

[Prescriptions of aerosol therapy. A survey of practices at the Besançon University Hospital].

OBJECTIVE: Prescriptions of aerosol sprays concomitantly with other drugs can raise problems of incompatibility. METHODS: Medical practices in the clinical units of the Besançon University Hospital were analyzed to assess the therapeutic indications, the most frequently prescribed drugs, possible admixtures, the nature and volume of solvents used, drug protocols and type of aerosol therapy and nebulizer used. Sixty questionnaires were sent to all the units of the University Teaching Hospital of Besançon. RESULTS: Analysis of 48 questionnaires completed by head nurses showed that 28 different drugs and 26 different admixtures were prescribed. Only 2 of the admixtures had undergone prior validation. Only 7 (26%) of the drug formulations prescribed had received marketing approval. Recognized clinical practices for the administration of aerosol therapy were not applied and the aerosol sessions were not standardized. CONCLUSION: Many prescriptions are carried out without knowledge of the chemical compatibility of co-administered medicines.

Administration, Inhalation↗