Biomedical subjects
Publications and source records attributed to T Herman.
Bronchial secretions from 191 children with various respiratory diseases and from 7 healthy controls were tested for concentration of ceruloplasmin, haptoglobin and transferrin. Highest protein levels were observed in children with bronchiectasis and cystic fibrosis. The protein levels were correlated with the intensity of the inflammatory process.
In 84 patients, aged 23 to 84, with primary hypothyroidism, the daily dose of thyroxine needed to lower the serum thyrotropin level into the normal range was significantly less in older patients than in younger ones (p less than 0.01). Most of the difference between middle-aged (40 to 60 years) and older patients (greater than 60 years) was due to a decrease in the required dose in men; there was no difference in the dose needed by women in these age groups. Previous hyperthyroidism did not affect the dose of thyroxine required; it is unlikely that residual autonomous thyroid tissue affected the dose. Although the wide range of doses needed precludes use of these data in calculating a dose of thyroxine for an individual patient, doses of 100 micrograms per day or less were common in patients over age 40, and a few patients over age 60 needed 50 micrograms per day or less. Thus, (1) there is a sound physiologic basis for the common practice of using low doses of thyroxine, e.g., 25 micrograms per day, as initial therapy in older hypothyroid patients and (2) it may be reasonable to reassess the dose of thyroxine after several years in older patients.
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The concentration of immunoglobulins, lactoferrin and lysozyme we compared in bronchial secretions obtained from children with various chronic lung diseases. The IgG, lactoferrin and lysozyme, but not secretory IgA, concentrations were shown to be increased during chronic inflammatory response.
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The rate of phagocytosis and intracellular killing of staphylococcal mutants of different cell wall structure or those deprived of alpha-toxin production was studied in vivo in guinea pig peritoneal cavity. All mutants were ingested and killed at minor rates than standard S. aureus strains but only in the first hour of the observations.
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Cytological examination of the fluid from subdural hygromas revealed congenital Toxoplasmosis in 14 of 43 infants (32,5%). Conversely, subdural hygroma was a significant clinical symptom in 42 cases of congenital Toxoplasmosis. In 9 cases trophozoites or cystes of Toxoplasma Gondii were found in the subdural fluid, and in 4 of these in the cerebrospinal fluid as well. Since serological investigations in young infants and particularly severe infections often remain inconclusive the cytological examination of cerebrospinal fluid is emphasized importance of.
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Pulmonary sequestration is a spectrum of related lesions, each of which may be absent or present: (1) bronchial sequestration of pulmonary parenchyma; (2) arterial supply from systemic circulation; (3) anomalous pulmonary venous drainage to the right atrium; (4) communications between bronchus and esophagus; (5) defects of diaphragm; (6) gross lung anomalies, such as horseshoe lungs or hypoplasia. Any combination of these primary lesions can occur in an individual patient. Diagnosis should be directed towards each component of the spectrum. Of special importance is the venous connection, as anomalous pulmonary venous drainage can involve not only the sequestered segment but the entire ipsilateral lung, making surgical therapy far more complex. Treatment of choice is surgical resection, associated, if needed, with rerouting of the pulmonary venous return. Classification of sequestration of the lung as intra- and extralobar is of secondary importance: these 2 groups do not represent lesions of different embryological significance.
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